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Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors.
Cernak, Tim; Gesmundo, Nathan J; Dykstra, Kevin; Yu, Yang; Wu, Zhicai; Shi, Zhi-Cai; Vachal, Petr; Sperbeck, Donald; He, Shuwen; Murphy, Beth Ann; Sonatore, Lisa; Williams, Steven; Madeira, Maria; Verras, Andreas; Reiter, Maud; Lee, Claire Heechoon; Cuff, James; Sherer, Edward C; Kuethe, Jeffrey; Goble, Stephen; Perrotto, Nicholas; Pinto, Shirly; Shen, Dong-Ming; Nargund, Ravi; Balkovec, James; DeVita, Robert J; Dreher, Spencer D.
Afiliación
  • Cernak T; Department of Discovery Chemistry, MRL, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
  • Gesmundo NJ; Department of Discovery Chemistry, MRL, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
  • Dykstra K; Department of Discovery Chemistry, MRL, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
  • Yu Y; Department of Discovery Chemistry, MRL, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
  • Wu Z; Department of Discovery Chemistry, MRL, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
  • Shi ZC; Department of Discovery Chemistry, MRL, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
  • Vachal P; Department of Discovery Chemistry, MRL, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
  • Sperbeck D; Department of Discovery Chemistry, MRL, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
  • He S; Department of Discovery Chemistry, MRL, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
  • Murphy BA; Department of Discovery Chemistry, MRL, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
  • Sonatore L; Department of Discovery Chemistry, MRL, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
  • Williams S; Department of Discovery Chemistry, MRL, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
  • Madeira M; Department of Discovery Chemistry, MRL, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
  • Verras A; Department of Discovery Chemistry, MRL, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
  • Reiter M; Department of Discovery Chemistry, MRL, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
  • Lee CH; Department of Discovery Chemistry, MRL, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
  • Cuff J; Department of Discovery Chemistry, MRL, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
  • Sherer EC; Department of Discovery Chemistry, MRL, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
  • Kuethe J; Department of Discovery Chemistry, MRL, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
  • Goble S; Department of Discovery Chemistry, MRL, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
  • Perrotto N; Department of Discovery Chemistry, MRL, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
  • Pinto S; Department of Discovery Chemistry, MRL, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
  • Shen DM; Department of Discovery Chemistry, MRL, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
  • Nargund R; Department of Discovery Chemistry, MRL, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
  • Balkovec J; Department of Discovery Chemistry, MRL, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
  • DeVita RJ; Department of Discovery Chemistry, MRL, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
  • Dreher SD; Department of Discovery Chemistry, MRL, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
J Med Chem ; 60(9): 3594-3605, 2017 05 11.
Article en En | MEDLINE | ID: mdl-28252959
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Inhibidores Enzimáticos / Diacilglicerol O-Acetiltransferasa Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Inhibidores Enzimáticos / Diacilglicerol O-Acetiltransferasa Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos