Absence of late-replicating X-chromosome in a female patient with acute myeloid leukemia and the 8;21 translocation.
J Natl Cancer Inst
; 62(2): 273-5, 1979 Feb.
Article
en En
| MEDLINE
| ID: mdl-283263
ABSTRACT
Autoradiography was used to demonstrate that the x-chromosome of the 45,X,-X,t(8;21) stemline of a female patient with acute myeloid leukemia (AML) was the active X-chromosome. This suggested that in patients housing AML with the 8;21 translocation, the loss of the inactive X-chromosome in females and of the Y in males (which is known to occur in nearly half of the patients) entails selective advantage to the stemline.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cromosomas Sexuales
/
Cromosoma X
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Leucemia Mieloide Aguda
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Aberraciones Cromosómicas
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Cromosomas Humanos 21-22 e Y
/
Cromosomas Humanos 6-12 y X
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
J Natl Cancer Inst
Año:
1979
Tipo del documento:
Article