ABL1, Abelson murine leukaemia virus; ALL, acute lymphoblastic leukaemia; AP, accelerated phase; ARQ, armored RNA Quant; ATP, adenosine triphosphate; BC, blast crisis; BCR, breakpoint cluster region; BM, bone marrow; BMT, bone marrow transplantation; Bp, base pair; CAP, College of American Pathology; CES, capillary electrophoresis sequencing; CML; CML, chronic myeloid leukaemia; CMR, complete molecular response/remission; CP, chronic phase; DESTINY, De-Escalation and Stopping Treatment of Imatinib, Nilotinib or sprYcel in Chronic Myeloid Leukaemia; DNA, deoxyribonucleic acid; EAC, Europe Against Cancer; ELN, European Leukaemia Net; EURO-SKI, European Stop Tyrosine Kinase Inhibitor Study; GUSB, glucuronidase beta gene; IC, inhibotory concentration; IRIS, interferon and cytarabine versus STI571; IS, International Scale; InDels, insertions and deletions; KDa, Kilo Dalton; Kbp, Kilo Base Pairs; LPC, leukemic progenitor cells; LSC, leukemic stem cell; LoD, limit of detection; LoQ, limit of quantification; M-bcr, major-breakpoint cluster region; MMR, major molecular response/remission; MR, deep molecular response/remission; MRD; MRD, minimal residual disease; Mbp, mega base pair; Molecular monitoring; NCCN, National Comprehensive Cancer Network; NEQAS, National External Quality Assessement Service; NGS; NGS, next generation sequencing; NTC, No Template Control; PB, Peripheral Blood; PCR, Polymerase Chain Reaction; PFS, Progression Free Survival; Ph, Philadelpia; Q-PCR, quantitative polymerase chain reaction; QC, Quality Control; RT, reverse transcription; RT-dPCR, reverse transcription-digital polymerase chain reaction; RT-qPCR, reverse transcription-quantitative polymerase chain reaction; SCT, stem cell transplant; SMRT, single-molecule real-time sequencing; STIM, stop imatinib; TKD, tyrosine kinase domain; TKI, tyrosine kinase inhibitor; WHO, World Health Organisation; ZMW, zero-mode wave-guided; allo-SCT, Allogeneic Stem Cell Transplantation; cDNA, coding or complimentary DNA; dMIQE, Minimum Information for Publication of Quantitative Digital PCR Experiments; dPCR; dPCR, digital polymerase chain reaction; emPCR, emulsion PCR; gDNA, genomic deoxyribonucleic acid; m-bcr, minor-breakpoint cluster region; mRNA, messenger RNA; nM, manomolar; µ-bcr, micro-breakpoint cluster region; µg, microgram; µl, microliter