Doubling time of thymic epithelial tumours on CT: correlation with histological subtype.
Eur Radiol
; 27(10): 4030-4036, 2017 Oct.
Article
en En
| MEDLINE
| ID: mdl-28332015
ABSTRACT
OBJECTIVES:
We retrospectively evaluated the doubling time (DT) of thymic epithelial tumours (TET) according to the histological subtype on CT.METHODS:
From January 2005 to June 2016, we enrolled 53 patients who had pathologically confirmed TET and at least two CT scans. Tumour size was measured using a two-dimensional method, and the DT was calculated. DTs were compared among histological subtypes, and factors associated with rapid tumour growth (DT <180 days) were assessed.RESULTS:
In 42 of the 53 patients (79.2%) the tumours showed interval growth (>2 mm) during follow-up. The median DT for all tumours was 400 days (range 48-1,964 days). There were no significant differences in DT in relation to histological subtype (p = 0.177). When TETs were recategorized into three groups, i.e. low-risk thymomas (types A, AB, B1), high-risk thymomas (types B2, B3), and thymic carcinoma, DT was significantly different among the groups (median DT 436, 381 and 189 days, respectively; p = 0.031). Histological subtype (type B3 and thymic carcinoma) was the single independent predictor of rapid tumour growth.CONCLUSIONS:
The majority of TETs grew during follow-up with variable and relatively slow growth rates. Histological features of aggressive behaviour significantly correlated with a decreased DT and rapid growth. KEY POINTS ⢠The majority of thymic epithelial tumours grew during follow-up (79.2%, 42/53). ⢠Doubling times of thymic epithelial tumours were highly variable (median 400 days). ⢠Histological features of aggressive behaviour significantly correlated with a decreased doubling time.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Timoma
/
Neoplasias del Timo
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Neoplasias Glandulares y Epiteliales
/
Carga Tumoral
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Eur Radiol
Asunto de la revista:
RADIOLOGIA
Año:
2017
Tipo del documento:
Article