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Interstitial pneumonitis after allogeneic bone marrow transplantation. Nine-year experience at a single institution.
Wingard, J R; Mellits, E D; Sostrin, M B; Chen, D Y; Burns, W H; Santos, G W; Vriesendorp, H M; Beschorner, W E; Saral, R.
Afiliación
  • Wingard JR; Johns Hopkins Medical, Oncology Center, Baltimore, Maryland 21205.
Medicine (Baltimore) ; 67(3): 175-86, 1988 May.
Article en En | MEDLINE | ID: mdl-2835573
Of 386 patients with allogeneic bone marrow transplants (BMT) treated during a 9-year interval, 166 developed interstitial pneumonitis (IP). Idiopathic and cytomegalovirus (CMV) IP constituted 90% of the 113 cases in which tissue was examined. Risk factors for IP overall were acute graft-versus-host disease (AGVHD), remote transplant date, the diagnosis of leukemia, and GVHD prophylaxis with agents other than cyclosporine. Risk factors for CMV IP were pre-transplant CMV seropositivity, CMV excretion, age greater than 10 years, AGVHD, GVHD prophylaxis with agents other than cyclosporine, and a remote transplant date. Patients transplanted for aplastic anemia were at lower risk for idiopathic IP than those transplanted for leukemia. The incidence of IP in patients given busulfan plus cyclophosphamide was equivalent to that in patients receiving cyclophosphamide plus total body irradiation. The incidence of idiopathic IP remained constant over this 9-year period while CMV IP declined significantly.
Asunto(s)
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fibrosis Pulmonar / Trasplante de Médula Ósea Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male País/Región como asunto: America do norte Idioma: En Revista: Medicine (Baltimore) Año: 1988 Tipo del documento: Article
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fibrosis Pulmonar / Trasplante de Médula Ósea Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male País/Región como asunto: America do norte Idioma: En Revista: Medicine (Baltimore) Año: 1988 Tipo del documento: Article