Efficacy and Safety of Tranexamic Acid in Melasma: A Meta-analysis and Systematic Review.
Acta Derm Venereol
; 97(7): 776-781, 2017 Jul 06.
Article
en En
| MEDLINE
| ID: mdl-28374042
ABSTRACT
Tranexamic acid is a novel treatment option for melasma; however, there is no consensus on its use. This systematic review searched major databases for relevant publications to March 2016. Eleven studies with 667 participants were included. Pooled data from tranexamic acid-only observational studies with pre- and post-treatment Melasma Area and Severity Index (MASI) showed a decrease of 1.60 in MASI (95% confidence interval (CI), 1.20-2.00; p<0.001) after treat-ment with tranexamic acid. The addition of tranexamic acid to routine treatment modalities resulted in a further decrease in MASI of 0.94 (95% CI 0.10-1.79; p = 0.03). Side-effects were minor, with a few cases reporting hypo-menorrhoea, mild abdominal discomfort, and transient skin irritation. These results support the efficacy and safety of tranexamic acid, either alone or as an adjuvant to routine treatment modalities for melasma.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ácido Tranexámico
/
Pigmentación de la Piel
/
Fármacos Dermatológicos
/
Melanosis
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Acta Derm Venereol
Año:
2017
Tipo del documento:
Article