HSPA8 as a novel fusion partner of NR4A3 in extraskeletal myxoid chondrosarcoma.
Genes Chromosomes Cancer
; 56(7): 582-586, 2017 07.
Article
en En
| MEDLINE
| ID: mdl-28383167
ABSTRACT
Extraskeletal myxoid chondrosarcoma (EMC) is a very rare sarcoma most often arising in the soft tissue. Rare EMC of the bone have been reported. EMC exhibits distinctive clinico-pathological and genetic features; however, despite the name, it lacks any feature of cartilaginous differentiation. EMC is characterized by the rearrangement of the NR4A3, which, in most cases (about 62-75%), is fused with EWSR1 and less frequently with other partners, including TAF15 (27%), TCF12 (4%), TFG, and FUS. We herein report the identification by whole-transcriptome sequencing of HSPA8 as a novel fusion partner of NR4A3 in a case of EMC. FISH analysis confirmed the presence of a genomic HSPA8-NR4A3 translocation in the vast majority of tumor cells. Our findings expand the spectrum of NR4A3 fusion partners involved in EMC pathobiology.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Receptores de Hormona Tiroidea
/
Receptores de Esteroides
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Proteínas de Fusión Oncogénica
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Condrosarcoma
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Neoplasias de los Tejidos Conjuntivo y Blando
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Proteínas de Unión al ADN
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Proteínas del Choque Térmico HSC70
Tipo de estudio:
Prognostic_studies
Límite:
Female
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Humans
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Middle aged
Idioma:
En
Revista:
Genes Chromosomes Cancer
Asunto de la revista:
BIOLOGIA MOLECULAR
/
NEOPLASIAS
Año:
2017
Tipo del documento:
Article
País de afiliación:
Italia