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A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection.
Niu, Xin; Brahmbhatt, Hetal; Mergenthaler, Philipp; Zhang, Zhi; Sang, Jing; Daude, Michael; Ehlert, Fabian G R; Diederich, Wibke E; Wong, Eve; Zhu, Weijia; Pogmore, Justin; Nandy, Jyoti P; Satyanarayana, Maragani; Jimmidi, Ravi K; Arya, Prabhat; Leber, Brian; Lin, Jialing; Culmsee, Carsten; Yi, Jing; Andrews, David W.
Afiliación
  • Niu X; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada; Department of Biochemistry and Molecular Cell Biology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • Brahmbhatt H; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada; Biological Sciences, Sunnybrook Research Institute, University of Toronto, Toronto, ON M4N 3M5, Canada.
  • Mergenthaler P; Biological Sciences, Sunnybrook Research Institute, University of Toronto, Toronto, ON M4N 3M5, Canada; Departments of Experimental Neurology and Neurology, Center for Stroke Research, NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Be
  • Zhang Z; Department of Biochemistry and Molecular Biology, Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73126, USA.
  • Sang J; Department of Biochemistry and Molecular Cell Biology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Biological Sciences, Sunnybrook Research Institute, University of Toronto, Toronto, ON M4N 3M5, Canada.
  • Daude M; Department of Medicinal Chemistry, Center for Tumor Biology and Immunology, Philipps Universität Marburg, 35043 Marburg, Germany.
  • Ehlert FGR; Department of Medicinal Chemistry, Center for Tumor Biology and Immunology, Philipps Universität Marburg, 35043 Marburg, Germany.
  • Diederich WE; Department of Medicinal Chemistry, Center for Tumor Biology and Immunology, Philipps Universität Marburg, 35043 Marburg, Germany.
  • Wong E; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada.
  • Zhu W; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada.
  • Pogmore J; Biological Sciences, Sunnybrook Research Institute, University of Toronto, Toronto, ON M4N 3M5, Canada.
  • Nandy JP; Drug Discovery Program, Ontario Institute for Cancer Research, MaRS Centre, Toronto, ON M5G 0A3, Canada.
  • Satyanarayana M; Drug Discovery Program, Ontario Institute for Cancer Research, MaRS Centre, Toronto, ON M5G 0A3, Canada.
  • Jimmidi RK; Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500046, India.
  • Arya P; Drug Discovery Program, Ontario Institute for Cancer Research, MaRS Centre, Toronto, ON M5G 0A3, Canada.
  • Leber B; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada; Department of Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada.
  • Lin J; Department of Biochemistry and Molecular Biology, Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73126, USA.
  • Culmsee C; Fachbereich Pharmazie, Institut für Pharmakologie und Klinische Pharmazie, Philipps Universität Marburg, 35043 Marburg, Germany.
  • Yi J; Department of Biochemistry and Molecular Cell Biology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • Andrews DW; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada; Biological Sciences, Sunnybrook Research Institute, University of Toronto, Toronto, ON M4N 3M5, Canada. Electronic address: david.andrews@sri.utoronto.ca.
Cell Chem Biol ; 24(4): 493-506.e5, 2017 Apr 20.
Article en En | MEDLINE | ID: mdl-28392146
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Apoptosis / Fármacos Neuroprotectores / Membranas Mitocondriales / Proteína X Asociada a bcl-2 / Proteína Destructora del Antagonista Homólogo bcl-2 / Bibliotecas de Moléculas Pequeñas Límite: Animals / Female / Humans / Male Idioma: En Revista: Cell Chem Biol Año: 2017 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Apoptosis / Fármacos Neuroprotectores / Membranas Mitocondriales / Proteína X Asociada a bcl-2 / Proteína Destructora del Antagonista Homólogo bcl-2 / Bibliotecas de Moléculas Pequeñas Límite: Animals / Female / Humans / Male Idioma: En Revista: Cell Chem Biol Año: 2017 Tipo del documento: Article País de afiliación: China