Function of Nup98 subtypes and their fusion proteins, Nup98-TopIIß and Nup98-SETBP1 in nuclear-cytoplasmic transport.
Biochem Biophys Res Commun
; 487(1): 96-102, 2017 May 20.
Article
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| MEDLINE
| ID: mdl-28392395
ABSTRACT
Nup98 is a component of the nuclear pore complex. The nup98-fusion genes derived by chromosome translocations are involved in hematopoietic malignancies. Here, we investigated the functions of Nup98 isoforms and two unexamined Nup98-fusion proteins, Nup98-TopIIß and Nup98-SETBP1. We first demonstrated that two Nup98 isoforms are expressed in various mouse tissues and similarly localized in the nucleus and the nuclear envelope. We also showed that Nup98-TopIIß and Nup98-SETBP1 are localized in the nucleus and partially co-localized with full-length Nup98 and a nuclear export receptor XPO1. We demonstrated that Nup98-TopIIß and Nup98-SETBP1 negatively regulate the XPO1-mediated protein export. Our results will contribute to the understanding of the molecular mechanism by which the Nup98-fusion proteins induce tumorigenesis.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas Nucleares
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Proteínas Portadoras
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Núcleo Celular
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ADN-Topoisomerasas de Tipo II
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Proteínas de Transporte Nucleocitoplasmático
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Proteínas de Complejo Poro Nuclear
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Proteínas de Unión al ADN
Límite:
Animals
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Humans
Idioma:
En
Revista:
Biochem Biophys Res Commun
Año:
2017
Tipo del documento:
Article