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Synchronization and variability imbalance underlie cognitive impairment in primary-progressive multiple sclerosis.
Petracca, Maria; Saiote, Catarina; Bender, Heidi A; Arias, Franchesca; Farrell, Colleen; Magioncalda, Paola; Martino, Matteo; Miller, Aaron; Northoff, Georg; Lublin, Fred; Inglese, Matilde.
Afiliación
  • Petracca M; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.
  • Saiote C; Department of Neuroscience, Reproductive Sciences and Odontostomatology, University of Naples "Federico II", Naples, 80131, Italy.
  • Bender HA; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.
  • Arias F; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.
  • Farrell C; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.
  • Magioncalda P; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.
  • Martino M; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Mother-Child health, University of Genoa, Genoa, 16132, Italy.
  • Miller A; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Mother-Child health, University of Genoa, Genoa, 16132, Italy.
  • Northoff G; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.
  • Lublin F; Institute of Mental Health Research, University of Ottawa, Ottawa, K1Z 7K4, Canada.
  • Inglese M; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.
Sci Rep ; 7: 46411, 2017 04 21.
Article en En | MEDLINE | ID: mdl-28429774
ABSTRACT
We aimed to investigate functional connectivity and variability across multiple frequency bands in brain networks underlying cognitive deficits in primary-progressive multiple sclerosis (PP-MS) and to explore how they are affected by the presence of cortical lesions (CLs). We analyzed functional connectivity and variability (measured as the standard deviation of BOLD signal amplitude) in resting state networks (RSNs) associated with cognitive deficits in different frequency bands in 25 PP-MS patients (12 M, mean age 50.9 ± 10.5 years) and 20 healthy subjects (9 M, mean age 51.0 ± 9.8 years). We confirmed the presence of a widespread cognitive deterioration in PP-MS patients, with main involvement of visuo-spatial and executive domains. Cognitively impaired patients showed increased variability, reduced synchronicity between networks involved in the control of cognitive macro-domains and hyper-synchronicity limited to the connections between networks functionally more segregated. CL volume was higher in patients with cognitive impairment and was correlated with functional connectivity and variability. We demonstrate, for the first time, that a functional reorganization characterized by hypo-synchronicity of functionally-related/hyper-synchronicity of functionally-segregated large scale networks and an abnormal pattern of neural activity underlie cognitive dysfunction in PP-MS, and that CLs possibly play a role in variability and functional connectivity abnormalities.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Encéfalo / Sincronización Cortical / Esclerosis Múltiple Crónica Progresiva / Disfunción Cognitiva Tipo de estudio: Etiology_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Encéfalo / Sincronización Cortical / Esclerosis Múltiple Crónica Progresiva / Disfunción Cognitiva Tipo de estudio: Etiology_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos