Myocyte enhancer factor 2D promotes colorectal cancer angiogenesis downstream of hypoxia-inducible factor 1&#945;.

Xiang, Junyu; Sun, Hui; Su, Li; Liu, Limei; Shan, Juanjuan; Shen, Junjie; Yang, Zhi; Chen, Jun; Zhong, Xing; Ávila, Matías A; Yan, Xiaochu; Liu, Chungang; Qian, Cheng

Myocyte enhancer factor 2D promotes colorectal cancer angiogenesis downstream of hypoxia-inducible factor 1α.

Xiang, Junyu; Sun, Hui; Su, Li; Liu, Limei; Shan, Juanjuan; Shen, Junjie; Yang, Zhi; Chen, Jun; Zhong, Xing; Ávila, Matías A; Yan, Xiaochu; Liu, Chungang; Qian, Cheng.

Afiliación

Xiang J; Center of Biotherapy, Southwest Hospital, Third Military Medical University, Chongqing, China.
Sun H; Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing, China.
Su L; Department of Oncology, Chinese Traditional Medicine Hospital, Chongqing, China.
Liu L; Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing, China.
Shan J; Center of Biotherapy, Southwest Hospital, Third Military Medical University, Chongqing, China.
Shen J; Center of Biotherapy, Southwest Hospital, Third Military Medical University, Chongqing, China.
Yang Z; Center of Biotherapy, Southwest Hospital, Third Military Medical University, Chongqing, China.
Chen J; Center of Biotherapy, Southwest Hospital, Third Military Medical University, Chongqing, China.
Zhong X; Center of Biotherapy, Southwest Hospital, Third Military Medical University, Chongqing, China.
Ávila MA; Center of Investigation for Applied Medcine, University of Navarra, Pamplona, Spain.
Yan X; Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing, China. Electronic address: yxcwq@163.com.
Liu C; Center of Biotherapy, Southwest Hospital, Third Military Medical University, Chongqing, China. Electronic address: liuchungang@zju.edu.cn.
Qian C; Center of Biotherapy, Southwest Hospital, Third Military Medical University, Chongqing, China. Electronic address: cqian8634@gmail.com.

Cancer Lett ; 400: 117-126, 2017 08 01.

Article en En | MEDLINE | ID: mdl-28478181

Asunto(s)

Biomarcadores de Tumor/metabolismo; Neoplasias Colorrectales/metabolismo; Subunidad alfa del Factor 1 Inducible por Hipoxia/metabolismo; Neovascularización Patológica; Animales; Sitios de Unión; Biomarcadores de Tumor/genética; Células CACO-2; Neoplasias Colorrectales/irrigación sanguínea; Neoplasias Colorrectales/genética; Neoplasias Colorrectales/patología; Medios de Cultivo Condicionados/metabolismo; Citocinas/metabolismo; Femenino; Regulación Neoplásica de la Expresión Génica; Células HCT116; Células HT29; Células Endoteliales de la Vena Umbilical Humana/metabolismo; Humanos; Subunidad alfa del Factor 1 Inducible por Hipoxia/genética; Factores de Transcripción MEF2/genética; Factores de Transcripción MEF2/metabolismo; Masculino; Ratones Endogámicos BALB C; Ratones Desnudos; Microvasos/metabolismo; Microvasos/patología; Persona de Mediana Edad; Comunicación Paracrina; Molécula-1 de Adhesión Celular Endotelial de Plaqueta/metabolismo; Pronóstico; Regiones Promotoras Genéticas; Interferencia de ARN; Transducción de Señal; Factores de Tiempo; Activación Transcripcional; Transfección; Carga Tumoral; Hipoxia Tumoral; Microambiente Tumoral

Palabras clave

Angiogenesis; Colorectal cancer; HIF-1α; MEF2D

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Biomarcadores de Tumor / Subunidad alfa del Factor 1 Inducible por Hipoxia / Neovascularización Patológica Tipo de estudio: Prognostic_studies Idioma: En Revista: Cancer Lett Año: 2017 Tipo del documento: Article País de afiliación: China

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