Bivalent O-glycoside mimetics with S/disulfide/Se substitutions and aromatic core: Synthesis, molecular modeling and inhibitory activity on biomedically relevant lectins in assays of increasing physiological relevance.

Kaltner, Herbert; Szabó, Tamás; Fehér, Krisztina; André, Sabine; Balla, Sára; Manning, Joachim C; Szilágyi, László; Gabius, Hans-Joachim

Kaltner, Herbert; Szabó, Tamás; Fehér, Krisztina; André, Sabine; Balla, Sára; Manning, Joachim C; Szilágyi, László; Gabius, Hans-Joachim.

Afiliación

Kaltner H; Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig-Maximilians-University Munich, Veterinärstr. 13, 80539 München, Germany.
Szabó T; Department of Chemistry, University of Debrecen, PO Box 20, 4010 Debrecen, Hungary; Richter Gedeon Rt., Gyömröi út 19-21, 1103 Budapest, Hungary.
Fehér K; NMR and Structural Analysis Unit, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281, 9000 Ghent, Belgium.
André S; Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig-Maximilians-University Munich, Veterinärstr. 13, 80539 München, Germany.
Balla S; Department of Chemistry, University of Debrecen, PO Box 20, 4010 Debrecen, Hungary.
Manning JC; Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig-Maximilians-University Munich, Veterinärstr. 13, 80539 München, Germany.
Szilágyi L; Department of Chemistry, University of Debrecen, PO Box 20, 4010 Debrecen, Hungary. Electronic address: lszilagyi@unideb.hu.
Gabius HJ; Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig-Maximilians-University Munich, Veterinärstr. 13, 80539 München, Germany. Electronic address: gabius@tiph.vetmed.uni-muenchen.de.

Bioorg Med Chem ; 25(12): 3158-3170, 2017 06 15.

Article en En | MEDLINE | ID: mdl-28483453

Asunto(s)

Glicósidos/química; Glicósidos/farmacología; Lectinas/antagonistas & inhibidores; Animales; Derivados del Benceno/química; Derivados del Benceno/farmacología; Línea Celular Tumoral; Disulfuros/química; Disulfuros/farmacología; Humanos; Lectinas/análisis; Ratones Endogámicos C57BL; Modelos Moleculares; Naftalenos/química; Naftalenos/farmacología; Compuestos de Organoselenio/química; Compuestos de Organoselenio/farmacología

Palabras clave

Agglutinin; Glycosyldisulfides; Histochemistry; Lectin; Selenoglycosides; Sugar code; Thioglycosides

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Glicósidos / Lectinas Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Alemania

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