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Resurgence of rabies in Hungary during 2013-2014: An attempt to track the origin of identified strains.
Hornyák, Á; Juhász, T; Forró, B; Kecskeméti, S; Bányai, K.
Afiliación
  • Hornyák Á; Veterinary Diagnostic Directorate, National Food Chain Safety Office, Budapest, Hungary.
  • Juhász T; Veterinary Diagnostic Directorate, National Food Chain Safety Office, Budapest, Hungary.
  • Forró B; Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Budapest, Hungary.
  • Kecskeméti S; Veterinary Diagnostic Directorate, National Food Chain Safety Office, Debrecen, Hungary.
  • Bányai K; Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Budapest, Hungary.
Transbound Emerg Dis ; 65(1): e14-e24, 2018 Feb.
Article en En | MEDLINE | ID: mdl-28497505
In 2013-2014, accumulation of rabies episodes raised concerns regarding ongoing elimination programme in Hungary. Nearly four dozen cases were identified over a 13-month period in the central region of the country far behind the immunization zones. Although the outbreak was successfully controlled, the origin of disease remained unknown. In this study, we sequenced the partial N and G genes from 47 Hungarian rabies virus (RV) strains isolated from the 2013-2014 outbreak. Sequencing and phylogenetic analysis of the N and G genes showed that the Hungarian RV isolates share high nucleotide similarity among each other (up to 100%). When analysing the N gene, comparable sequence similarity was seen between the outbreak strains and some historic Romanian RV strains. Unfortunately, in the lack of available sequence data from the Romanian RV strains, the genetic relationship within the G gene could not be determined. Phylogenetic analysis of Hungarian RV isolates detected in the past revealed that multiple independent RV lineages circulated in our country over the past 25 years. The parental strain of the 2013-2014 outbreak may have been imported independently perhaps from east through transborder movement of a reservoir animal. Next to the introduction, this imported RV strain seems to have spread clonally in the affected area. Our findings indicate that despite effective control measures that, overall, minimized the incidence of rabies over the past decade, field and laboratory monitoring needs to be continued to make rabies elimination programme in Hungary successful.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Rabia / Virus de la Rabia / Enfermedades de los Bovinos / Brotes de Enfermedades / Zorros Tipo de estudio: Prognostic_studies Límite: Animals País/Región como asunto: Europa Idioma: En Revista: Transbound Emerg Dis Asunto de la revista: MEDICINA VETERINARIA Año: 2018 Tipo del documento: Article País de afiliación: Hungria

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Rabia / Virus de la Rabia / Enfermedades de los Bovinos / Brotes de Enfermedades / Zorros Tipo de estudio: Prognostic_studies Límite: Animals País/Región como asunto: Europa Idioma: En Revista: Transbound Emerg Dis Asunto de la revista: MEDICINA VETERINARIA Año: 2018 Tipo del documento: Article País de afiliación: Hungria