Ivermectin lipid-based nanocarriers as novel formulations against head lice.
Parasitol Res
; 116(8): 2111-2117, 2017 Aug.
Article
en En
| MEDLINE
| ID: mdl-28523490
ABSTRACT
The use of pyrethroids to control the human head louse, Pediculus humanus capitis De Geer (Anoplura Pediculidae), has suffered considerable loss of efficacy due to the evolution of resistance. Thus, the development of efficiently insecticide delivery systems is imperative for the control of head lice. We studied the insecticidal activity of ivermectin-loaded lipid nanocapsules (IVM-LNC) against permethrin-resistant head lice from Argentina. The LNC, prepared by a phase inversion procedure, were characterized in terms of size, surface potential, and physical stability. These nanoparticles were nearly spherical with mean diameters of 55 nm and narrow size distribution (PI ≤ 0.2). The KT50 mortality values of head lice after exposure to two IVM-LNC formulations (0.11 and 0.28%) were significantly smaller (5 and 3 h, respectively) compared to those exposed only to LNC control group (8 h). This investigation showed the effectiveness in the encapsulation of ivermectin (IVM) into stable LNC dispersion with a potential clinical activity against head lice.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Infestaciones por Piojos
/
Pediculus
/
Ivermectina
/
Permetrina
/
Insecticidas
Límite:
Animals
/
Humans
País/Región como asunto:
America do sul
/
Argentina
Idioma:
En
Revista:
Parasitol Res
Asunto de la revista:
PARASITOLOGIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Argentina