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Mismatch negativity (MMN) to spatial deviants and behavioral spatial discrimination ability in the etiology of auditory verbal hallucinations and thought disorder in schizophrenia.
Perrin, Megan A; Kantrowitz, Joshua T; Silipo, Gail; Dias, Elisa; Jabado, Omar; Javitt, Daniel C.
Afiliación
  • Perrin MA; Schizophrenia Research Center, Nathan Kline Institute for Psychiatric Research, United States; Department of Clinical Neuropsychology, Queens College, United States; The Graduate Center, City University of New York, United States.
  • Kantrowitz JT; Schizophrenia Research Center, Nathan Kline Institute for Psychiatric Research, United States; Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, United States.
  • Silipo G; Schizophrenia Research Center, Nathan Kline Institute for Psychiatric Research, United States.
  • Dias E; Schizophrenia Research Center, Nathan Kline Institute for Psychiatric Research, United States.
  • Jabado O; Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, United States.
  • Javitt DC; Schizophrenia Research Center, Nathan Kline Institute for Psychiatric Research, United States; Department of Psychiatry, Columbia College of Physicians and Surgeons, United States. Electronic address: dcj2113@columbia.edu.
Schizophr Res ; 191: 140-147, 2018 01.
Article en En | MEDLINE | ID: mdl-28532686
ABSTRACT
Persistent auditory verbal hallucinations (AVH) in schizophrenia are increasingly tied to dysfunction at the level of auditory cortex. AVH may reflect in part misattribution of internally generated thoughts to external spatial locations. Here, we investigated the association between persistent AVH and spatial localization abilities assessed both behaviorally and by mismatch negativity (MMN) to location deviants.

METHODS:

Spatial- and tonal- discrimination abilities were assessed in patients (n=20) and controls (n=20) using free-field tones. MMN was assessed to spatial-location-, pitch- and duration-deviants. AVH and thought disorder were assessed using clinical evaluation.

RESULTS:

As predicted, patients showed significant reductions in behavioral spatial-discrimination (p<0.0001) and tone-matching (p<0.001) ability, along with impaired MMN generation to location (p<0.03) and pitch (p<0.05) deviants. Hallucinating (AVH+) and non-hallucinating (AVH-) subjects showed similar deficits in location MMN to left-hemifield stimuli (p<0.0001 vs. control). By contrast, AVH- patients differed significantly from controls (p=0.009) and AVH+ patients (p=0.018) for MMN to right-lateral hemifield (left auditory cortex) stimuli, whereas AVH+ patients showed paradoxically preserved MMN generation (p=0.99 vs. controls). Severity of thought disorder correlated with impaired spatial discrimination, especially to right-hemifield stimuli (p=0.013), but did not correlate significantly with MMN or tone matching deficits.

CONCLUSION:

These findings demonstrate a significant relationship between auditory cortical spatial localization abilities and AVH susceptibility, with relatively preserved function of left vs. right auditory cortex predisposing to more severe AVH, and support models that attribute persistent AVH to impaired source-monitoring. The findings suggest new approaches for therapeutic intervention for both AVH and thought disorder in schizophrenia.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Esquizofrenia / Variación Contingente Negativa / Potenciales Evocados Auditivos / Alucinaciones Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Schizophr Res Asunto de la revista: PSIQUIATRIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Esquizofrenia / Variación Contingente Negativa / Potenciales Evocados Auditivos / Alucinaciones Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Schizophr Res Asunto de la revista: PSIQUIATRIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos