Multifunctional Effects of a Small-Molecule STAT3 Inhibitor on NASH and Hepatocellular Carcinoma in Mice.

Jung, Kwang Hwa; Yoo, Wonbeak; Stevenson, Heather L; Deshpande, Dipti; Shen, Hong; Gagea, Mihai; Yoo, Suk-Young; Wang, Jing; Eckols, T Kris; Bharadwaj, Uddalak; Tweardy, David J; Beretta, Laura

Jung, Kwang Hwa; Yoo, Wonbeak; Stevenson, Heather L; Deshpande, Dipti; Shen, Hong; Gagea, Mihai; Yoo, Suk-Young; Wang, Jing; Eckols, T Kris; Bharadwaj, Uddalak; Tweardy, David J; Beretta, Laura.

Afiliación

Jung KH; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Yoo W; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Stevenson HL; Department of Pathology, University of Texas Medical Branch, Galveston, Texas.
Deshpande D; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Shen H; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Gagea M; Department of Veterinary Medicine & Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas.
Yoo SY; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Wang J; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Eckols TK; Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Bharadwaj U; Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Tweardy DJ; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Beretta L; Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Clin Cancer Res ; 23(18): 5537-5546, 2017 Sep 15.

Article en En | MEDLINE | ID: mdl-28533225

Asunto(s)

Carcinoma Hepatocelular/metabolismo; Neoplasias Hepáticas/metabolismo; Naftoles/farmacología; Enfermedad del Hígado Graso no Alcohólico/metabolismo; Factor de Transcripción STAT3/antagonistas & inhibidores; Sulfonamidas/farmacología; Animales; Antineoplásicos/farmacología; Biopsia; Carcinoma Hepatocelular/diagnóstico; Carcinoma Hepatocelular/tratamiento farmacológico; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Supervivencia Celular/efectos de los fármacos; Citocinas/metabolismo; Modelos Animales de Enfermedad; Perfilación de la Expresión Génica; Humanos; Inmunohistoquímica; Mediadores de Inflamación; Pruebas de Función Hepática; Neoplasias Hepáticas/tratamiento farmacológico; Neoplasias Hepáticas/patología; Imagen por Resonancia Magnética; Ratones; Ratones Noqueados; Enfermedad del Hígado Graso no Alcohólico/diagnóstico; Enfermedad del Hígado Graso no Alcohólico/tratamiento farmacológico; Fosfohidrolasa PTEN/genética; Fosfohidrolasa PTEN/metabolismo; Transducción de Señal/efectos de los fármacos; Ensayos Antitumor por Modelo de Xenoinjerto

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sulfonamidas / Carcinoma Hepatocelular / Factor de Transcripción STAT3 / Enfermedad del Hígado Graso no Alcohólico / Neoplasias Hepáticas / Naftoles Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Clin Cancer Res Asunto de la revista: NEOPLASIAS Año: 2017 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google