Similar familial underpinnings for full and subsyndromal pediatric bipolar disorder: A familial risk analysis.
Bipolar Disord
; 19(3): 168-175, 2017 05.
Article
en En
| MEDLINE
| ID: mdl-28544732
ABSTRACT
OBJECTIVES:
To examine the validity of subthreshold pediatric bipolar I disorder (BP-I), we compared the familial risk for BP-I in the child probands who had either full BP-I, subthreshold BP-I, ADHD, or were controls that neither had ADHD nor bipolar disorder.METHODS:
BP-I probands were youth aged 6-17 years meeting criteria for BP-I, full (N=239) or subthreshold (N=43), and also included were their first-degree relatives (N=687 and N=120, respectively). Comparators were youth with ADHD (N=162), controls without ADHD or bipolar disorder (N=136), and their first-degree relatives (N=511 and N=411, respectively). We randomly selected 162 non-bipolar ADHD probands and 136 non-bipolar, non-ADHD control probands of similar age and sex distribution to the BP-I probands from our case-control ADHD family studies. Psychiatric assessments were made by trained psychometricians using the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children Epidemiological Version (KSADS-E) and Structured Clinical Interview for DSM-IV (SCID) structured diagnostic interviews. We analyzed rates of bipolar disorder using multinomial logistic regression.RESULTS:
Rates of full BP-I significantly differed between the four groups (χ23 =32.72, P<.001) relatives of full BP-I probands and relatives of subthreshold BP-I probands had significantly higher rates of full BP-I than relatives of ADHD probands and relatives of control probands. Relatives of full BP-I, subthreshold BP-I, and ADHD probands also had significantly higher rates of major depressive disorder compared to relatives of control probands.CONCLUSIONS:
Our results showed that youth with subthreshold BP-I had similarly elevated risk for BP-I and major depressive disorder in first-degree relatives as youth with full BP-I. These findings support the diagnostic continuity between subsyndromal and fully syndromatic states of pediatric BP-I disorder.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Trastorno Bipolar
/
Medición de Riesgo
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Enfermedades Asintomáticas
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
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Observational_studies
/
Qualitative_research
/
Risk_factors_studies
Límite:
Adolescent
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Child
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Female
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Humans
/
Male
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Bipolar Disord
Asunto de la revista:
PSIQUIATRIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos