Genetic and Pharmacological Reversibility of Phenotypes in Mouse Models of Autism Spectrum Disorder.
Adv Anat Embryol Cell Biol
; 224: 189-211, 2017.
Article
en En
| MEDLINE
| ID: mdl-28551757
ABSTRACT
As autism spectrum disorder (ASD) is largely regarded as a neurodevelopmental condition, long-time consensus was that its hallmark features are irreversible. However, several studies from recent years using defined mouse models of ASD have provided clear evidence that in mice neurobiological and behavioural alterations can be ameliorated or even reversed by genetic restoration or pharmacological treatment either before or after symptom onset. Here, we review findings on genetic and pharmacological reversibility of phenotypes in mouse models of ASD. Our review should give a comprehensive overview on both aspects and encourage future studies to better understand the underlying molecular mechanisms that might be translatable from animals to humans.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Trastorno del Espectro Autista
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Adv Anat Embryol Cell Biol
Año:
2017
Tipo del documento:
Article
País de afiliación:
Alemania