Jaspine B induces nonapoptotic cell death in gastric cancer cells independently of its inhibition of ceramide synthase.

Cingolani, Francesca; Simbari, Fabio; Abad, Jose Luis; Casasampere, Mireia; Fabrias, Gemma; Futerman, Anthony H; Casas, Josefina

Cingolani, Francesca; Simbari, Fabio; Abad, Jose Luis; Casasampere, Mireia; Fabrias, Gemma; Futerman, Anthony H; Casas, Josefina.

Afiliación

Cingolani F; Research Unit on BioActive Molecules (RUBAM), Department of Biomedicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain. Electronic address: fcingol@emory.edu.
Simbari F; Research Unit on BioActive Molecules (RUBAM), Department of Biomedicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain.
Abad JL; Research Unit on BioActive Molecules (RUBAM), Department of Biomedicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain.
Casasampere M; Research Unit on BioActive Molecules (RUBAM), Department of Biomedicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain.
Fabrias G; Research Unit on BioActive Molecules (RUBAM), Department of Biomedicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain.
Futerman AH; Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel.
Casas J; Research Unit on BioActive Molecules (RUBAM), Department of Biomedicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain. Electronic address: fina.casas@iqac.csic.es.

J Lipid Res ; 58(8): 1500-1513, 2017 08.

Article en En | MEDLINE | ID: mdl-28572516

Asunto(s)

Muerte Celular/efectos de los fármacos; Oxidorreductasas/antagonistas & inhibidores; Esfingosina/análogos & derivados; Neoplasias Gástricas/patología; Acilación/efectos de los fármacos; Apoptosis/efectos de los fármacos; Línea Celular Tumoral; Supervivencia Celular/efectos de los fármacos; Humanos; Pinocitosis/efectos de los fármacos; Esfingosina/farmacología; Vacuolas/efectos de los fármacos; Vacuolas/metabolismo

Palabras clave

anticancer drug; autophagy; liquid chromatography-mass spectrometry; methuosis; sphingolipid

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oxidorreductasas / Esfingosina / Neoplasias Gástricas / Muerte Celular Límite: Humans Idioma: En Revista: J Lipid Res Año: 2017 Tipo del documento: Article

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