Immunological Functions of the Omentum.
Trends Immunol
; 38(7): 526-536, 2017 07.
Article
en En
| MEDLINE
| ID: mdl-28579319
ABSTRACT
The omentum is a visceral adipose tissue with unique immune functions. Although it is primarily an adipose tissue, the omentum also contains lymphoid aggregates, called milky spots (MSs), that contribute to peritoneal immunity by collecting antigens, particulates, and pathogens from the peritoneal cavity and, depending on the stimuli, promoting a variety of immune responses, including inflammation, tolerance, or even fibrosis. Reciprocal interactions between cells in the MS and adipocytes regulate their immune and metabolic functions. Importantly, the omentum collects metastasizing tumor cells and supports tumor growth by immunological and metabolic mechanisms. Here we summarize our current knowledge about the development, organization, and function of the omentum in peritoneal immunity.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Epiplón
/
Linfocitos B
/
Citocinas
/
Linfocitos T Reguladores
/
Receptores de Citocinas
/
Tejido Linfoide
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos