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Continuous synthesis and anti-myocardial injury of tanshinone IIA derivatives.
Qin, Yin-Lin; Chen, Lei; He, Wei; Su, Mei; Jin, Qiu; Fang, Zheng; Ouyang, Ping-Kai; Guo, Kai.
Afiliación
  • Qin YL; a College of Biotechnology and Pharmaceutical Engineering , Nanjing Technology University , Nanjing 211816 , China.
  • Chen L; b Jiangsu Carephar Pharmaceutical Co., Ltd , Nanjing 210014 , China.
  • He W; c Department of Chemistry , Fudan University , Shanghai 200433 , China.
  • Su M; b Jiangsu Carephar Pharmaceutical Co., Ltd , Nanjing 210014 , China.
  • Jin Q; b Jiangsu Carephar Pharmaceutical Co., Ltd , Nanjing 210014 , China.
  • Fang Z; a College of Biotechnology and Pharmaceutical Engineering , Nanjing Technology University , Nanjing 211816 , China.
  • Ouyang PK; a College of Biotechnology and Pharmaceutical Engineering , Nanjing Technology University , Nanjing 211816 , China.
  • Guo K; a College of Biotechnology and Pharmaceutical Engineering , Nanjing Technology University , Nanjing 211816 , China.
J Asian Nat Prod Res ; 20(2): 139-147, 2018 Feb.
Article en En | MEDLINE | ID: mdl-28595458
A series of tanshinone IIA derivatives were synthesized through sulfonation, slat-forming, chlorination, and amidation reactions. Meanwhile, anti-myocardial injury activity was evaluated in vitro. D8 and D9 exhibited a slightly higher anti-myocardial injury (5.78, 7.46 µM) activity compared with esmolol (8.12 µM). In addition, they also displayed a concentration-dependent inhibition on the anti-myocardial injury.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Abietanos Idioma: En Revista: J Asian Nat Prod Res Asunto de la revista: BOTANICA / QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: China
Texto completo
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Abietanos Idioma: En Revista: J Asian Nat Prod Res Asunto de la revista: BOTANICA / QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: China