Obese asthmatic patients have decreased surfactant protein A levels: Mechanisms and implications.

Lugogo, Njira; Francisco, Dave; Addison, Kenneth J; Manne, Akarsh; Pederson, William; Ingram, Jennifer L; Green, Cynthia L; Suratt, Benjamin T; Lee, James J; Sunday, Mary E; Kraft, Monica; Ledford, Julie G

Obese asthmatic patients have decreased surfactant protein A levels: Mechanisms and implications.

Lugogo, Njira; Francisco, Dave; Addison, Kenneth J; Manne, Akarsh; Pederson, William; Ingram, Jennifer L; Green, Cynthia L; Suratt, Benjamin T; Lee, James J; Sunday, Mary E; Kraft, Monica; Ledford, Julie G.

Afiliación

Lugogo N; Department of Medicine, Duke University Medical Center, Durham, NC.
Francisco D; Department of Medicine, University of Arizona, Tucson, Ariz.
Addison KJ; Department of Medicine, University of Arizona, Tucson, Ariz.
Manne A; Department of Medicine, University of Arizona, Tucson, Ariz.
Pederson W; Department of Medicine, University of Arizona, Tucson, Ariz.
Ingram JL; Department of Medicine, Duke University Medical Center, Durham, NC.
Green CL; Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC.
Suratt BT; Department of Medicine, University of Vermont, Burlington, Vt.
Lee JJ; Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, Ariz.
Sunday ME; Department of Pathology, Duke University Medical Center, Durham, NC.
Kraft M; Department of Medicine, University of Arizona, Tucson, Ariz.
Ledford JG; Department of Medicine, University of Arizona, Tucson, Ariz; Department of Immunobiology, University of Arizona, Tucson, Ariz. Electronic address: jledford@deptofmed.arizona.edu.

J Allergy Clin Immunol ; 141(3): 918-926.e3, 2018 03.

Article en En | MEDLINE | ID: mdl-28624607

Asunto(s)

Asma/inmunología; Pulmón/inmunología; Obesidad/inmunología; Proteína A Asociada a Surfactante Pulmonar/inmunología; Adolescente; Adulto; Anciano; Animales; Asma/genética; Asma/patología; Líquido del Lavado Bronquioalveolar; Femenino; Humanos; Pulmón/patología; Masculino; Ratones; Ratones Noqueados; Persona de Mediana Edad; Obesidad/genética; Obesidad/patología

Palabras clave

IL-6; Surfactant; TNF-α; asthma; eosinophils; eotaxin; epithelial cells; lung function; obesity; surfactant protein A

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Asma / Proteína A Asociada a Surfactante Pulmonar / Pulmón / Obesidad Límite: Adolescent / Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: J Allergy Clin Immunol Año: 2018 Tipo del documento: Article País de afiliación: Nueva Caledonia

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