Antibodies Against Immune Checkpoint Molecules Restore Functions of Tumor-Infiltrating T Cells in Hepatocellular Carcinomas.

Zhou, Guoying; Sprengers, Dave; Boor, Patrick P C; Doukas, Michail; Schutz, Hannah; Mancham, Shanta; Pedroza-Gonzalez, Alexander; Polak, Wojciech G; de Jonge, Jeroen; Gaspersz, Marcia; Dong, Haidong; Thielemans, Kris; Pan, Qiuwei; IJzermans, Jan N M; Bruno, Marco J; Kwekkeboom, Jaap

Antibodies Against Immune Checkpoint Molecules Restore Functions of Tumor-Infiltrating T Cells in Hepatocellular Carcinomas.

Zhou, Guoying; Sprengers, Dave; Boor, Patrick P C; Doukas, Michail; Schutz, Hannah; Mancham, Shanta; Pedroza-Gonzalez, Alexander; Polak, Wojciech G; de Jonge, Jeroen; Gaspersz, Marcia; Dong, Haidong; Thielemans, Kris; Pan, Qiuwei; IJzermans, Jan N M; Bruno, Marco J; Kwekkeboom, Jaap.

Afiliación

Zhou G; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Centre, Rotterdam, the Netherlands.
Sprengers D; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Centre, Rotterdam, the Netherlands.
Boor PPC; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Centre, Rotterdam, the Netherlands.
Doukas M; Department of Pathology, Erasmus MC-University Medical Centre, Rotterdam, the Netherlands.
Schutz H; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Centre, Rotterdam, the Netherlands.
Mancham S; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Centre, Rotterdam, the Netherlands.
Pedroza-Gonzalez A; Laboratory of Immunology Research, FES-Iztacala, UNAM, Mexico.
Polak WG; Department of Surgery, Erasmus MC-University Medical Centre, Rotterdam, the Netherlands.
de Jonge J; Department of Surgery, Erasmus MC-University Medical Centre, Rotterdam, the Netherlands.
Gaspersz M; Department of Surgery, Erasmus MC-University Medical Centre, Rotterdam, the Netherlands.
Dong H; Department of Urology and Immunology, Mayo Clinic College of Medicine, Rochester, Minnesota.
Thielemans K; Laboratory of Molecular and Cellular Therapy, Department of Immunology-Physiology, Vrije Universiteit, Brussels, and eTheRNA immunotherapies NV, Niel, Belgium.
Pan Q; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Centre, Rotterdam, the Netherlands.
IJzermans JNM; Laboratory of Immunology Research, FES-Iztacala, UNAM, Mexico.
Bruno MJ; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Centre, Rotterdam, the Netherlands.
Kwekkeboom J; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Centre, Rotterdam, the Netherlands. Electronic address: j.kwekkeboom@erasmusmc.nl.

Gastroenterology ; 153(4): 1107-1119.e10, 2017 10.

Article en En | MEDLINE | ID: mdl-28648905

Asunto(s)

Anticuerpos Monoclonales/farmacología; Anticuerpos Neutralizantes/farmacología; Antígenos CD; Antineoplásicos/farmacología; Carcinoma Hepatocelular/tratamiento farmacológico; Receptor 2 Celular del Virus de la Hepatitis A/antagonistas & inhibidores; Inmunoterapia/métodos; Neoplasias Hepáticas/tratamiento farmacológico; Linfocitos Infiltrantes de Tumor/efectos de los fármacos; Receptor de Muerte Celular Programada 1/antagonistas & inhibidores; Linfocitos T/efectos de los fármacos; Antígenos CD/inmunología; Antígenos CD/metabolismo; Protocolos de Quimioterapia Combinada Antineoplásica/farmacología; Antígeno CTLA-4/antagonistas & inhibidores; Antígeno CTLA-4/inmunología; Antígeno CTLA-4/metabolismo; Carcinoma Hepatocelular/inmunología; Carcinoma Hepatocelular/metabolismo; Carcinoma Hepatocelular/patología; Proliferación Celular/efectos de los fármacos; Células Cultivadas; Técnicas de Cocultivo; Citocinas/metabolismo; Receptor 2 Celular del Virus de la Hepatitis A/inmunología; Receptor 2 Celular del Virus de la Hepatitis A/metabolismo; Humanos; Neoplasias Hepáticas/inmunología; Neoplasias Hepáticas/metabolismo; Neoplasias Hepáticas/patología; Activación de Linfocitos/efectos de los fármacos; Linfocitos Infiltrantes de Tumor/inmunología; Linfocitos Infiltrantes de Tumor/metabolismo; Receptor de Muerte Celular Programada 1/inmunología; Receptor de Muerte Celular Programada 1/metabolismo; Transducción de Señal/efectos de los fármacos; Linfocitos T/inmunología; Linfocitos T/metabolismo; Escape del Tumor/efectos de los fármacos; Microambiente Tumoral; Regulación hacia Arriba; Proteína del Gen 3 de Activación de Linfocitos

Palabras clave

GPC3; Galectin 9; Immunotherapy; MAGEC2

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Linfocitos T / Antígenos CD / Linfocitos Infiltrantes de Tumor / Carcinoma Hepatocelular / Anticuerpos Neutralizantes / Receptor de Muerte Celular Programada 1 / Receptor 2 Celular del Virus de la Hepatitis A / Inmunoterapia / Neoplasias Hepáticas / Anticuerpos Monoclonales Idioma: En Revista: Gastroenterology Año: 2017 Tipo del documento: Article País de afiliación: Países Bajos

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