Phosphonic analogues of excitatory amino acids raise the threshold for maximal electroconvulsions in mice.
Neurosci Res
; 3(1): 86-90, 1985 Oct.
Article
en En
| MEDLINE
| ID: mdl-2868436
ABSTRACT
2-Amino-5-phosphonopentanoic acid (100 and 200 mg/kg) and 2-amino-7-phosphonoheptanoic acid (50-200 mg/kg i.p.) significantly elevated the threshold for maximal electroconvulsions in mice, the latter being more effective in this respect. In contrast, neither alpha-aminoadipic acid nor L-glutamic acid diethyl ester (up to 200 and 400 mg/kg, respectively) offered any protection. The present results add further evidence to support the importance of the blockade of N-methyl-D-aspartic acid receptor-mediated events in the suppression of seizure activity.
Buscar en Google
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Convulsiones
/
Valina
/
Aminoácidos
/
Aminoácidos Dicarboxílicos
/
Glutamatos
/
Ácido 2-Aminoadípico
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Neurosci Res
Asunto de la revista:
NEUROLOGIA
Año:
1985
Tipo del documento:
Article