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Expression and regulation of drug transporters in vertebrate neutrophils.
Foulkes, Matthew J; Henry, Katherine M; Rougeot, Julien; Hooper-Greenhill, Edward; Loynes, Catherine A; Jeffrey, Phil; Fleming, Angeleen; Savage, Caroline O; Meijer, Annemarie H; Jones, Simon; Renshaw, Stephen A.
Afiliación
  • Foulkes MJ; The Bateson Centre, The University of Sheffield, Sheffield, S10 2TN, UK.
  • Henry KM; Department of Chemistry, The University of Sheffield, Sheffield, S3 7HF, UK.
  • Rougeot J; Department of Infection, Immunity & Cardiovascular Disease, The University of Sheffield, Sheffield, S10 2RX, UK.
  • Hooper-Greenhill E; The Bateson Centre, The University of Sheffield, Sheffield, S10 2TN, UK.
  • Loynes CA; Department of Infection, Immunity & Cardiovascular Disease, The University of Sheffield, Sheffield, S10 2RX, UK.
  • Jeffrey P; Institute of Biology, University of Leiden, 2333 CC, Leiden, The Netherlands.
  • Fleming A; Immuno-Inflammation Therapy Area Unit, GlaxoSmithKline Research and Development Ltd., Stevenage, SG1 2NY, UK.
  • Savage CO; The Bateson Centre, The University of Sheffield, Sheffield, S10 2TN, UK.
  • Meijer AH; Department of Infection, Immunity & Cardiovascular Disease, The University of Sheffield, Sheffield, S10 2RX, UK.
  • Jones S; Rare Diseases Research Unit, Pfizer Ltd., Cambridge, CB21 6GP, UK.
  • Renshaw SA; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK.
Sci Rep ; 7(1): 4967, 2017 07 10.
Article en En | MEDLINE | ID: mdl-28694436
ABSTRACT
There remains a need to identify novel pro-resolution drugs for treatment of inflammatory disease. To date, there are no neutrophil-specific anti-inflammatory treatments in clinical use, perhaps due to our lack of understanding of how drugs access this complex cell type. Here we present the first comprehensive description and expression of both major classes of drug transporters, SLC and ABC, in resting human blood neutrophils. Moreover, we have studied the expression of these carriers in the tractable model system, the zebrafish (Danio rerio), additionally examining the evolutionary relationship between drug transporters in zebrafish and humans. We anticipate that this will be a valuable resource to the field of inflammation biology and will be an important asset in future anti-inflammatory drug design.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pez Cebra / Análisis de Secuencia de ARN / Transportadoras de Casetes de Unión a ATP / Proteínas Transportadoras de Solutos / Neutrófilos Límite: Animals / Humans Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pez Cebra / Análisis de Secuencia de ARN / Transportadoras de Casetes de Unión a ATP / Proteínas Transportadoras de Solutos / Neutrófilos Límite: Animals / Humans Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido