Epigenomic Consequences of Coding and Noncoding Driver Mutations.
Trends Cancer
; 2(10): 585-605, 2016 10.
Article
en En
| MEDLINE
| ID: mdl-28741489
ABSTRACT
Chromatin alterations are integral to the pathogenic process of cancer, as demonstrated by recent discoveries of frequent mutations in chromatin-modifier genes and aberrant DNA methylation states in different cancer types. Progress is being made on elucidating how chromatin alterations, and how proteins catalyzing these alterations, mechanistically contribute to tissue-specific tumorigenesis. In parallel, technologies enabling the genome-wide profiling of histone modifications have revealed the existence of noncoding driver genetic alterations in cancer. In this review, we survey the current knowledge of coding and noncoding cancer drivers, and discuss their impact on the chromatin landscape. Translational implications of these findings for novel cancer therapies are also presented.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cromatina
/
Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Cancer
Año:
2016
Tipo del documento:
Article
País de afiliación:
Singapur