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Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus.
Medina-Gomez, Carolina; Kemp, John P; Dimou, Niki L; Kreiner, Eskil; Chesi, Alessandra; Zemel, Babette S; Bønnelykke, Klaus; Boer, Cindy G; Ahluwalia, Tarunveer S; Bisgaard, Hans; Evangelou, Evangelos; Heppe, Denise H M; Bonewald, Lynda F; Gorski, Jeffrey P; Ghanbari, Mohsen; Demissie, Serkalem; Duque, Gustavo; Maurano, Matthew T; Kiel, Douglas P; Hsu, Yi-Hsiang; C J van der Eerden, Bram; Ackert-Bicknell, Cheryl; Reppe, Sjur; Gautvik, Kaare M; Raastad, Truls; Karasik, David; van de Peppel, Jeroen; Jaddoe, Vincent W V; Uitterlinden, André G; Tobias, Jonathan H; Grant, Struan F A; Bagos, Pantelis G; Evans, David M; Rivadeneira, Fernando.
Afiliación
  • Medina-Gomez C; Department of Internal Medicine, Erasmus MC University, Rotterdam, 3015GE, The Netherlands.
  • Kemp JP; The Generation R Study Group, Erasmus Medical Center, Rotterdam, 3015GE, The Netherlands.
  • Dimou NL; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015GE, The Netherlands.
  • Kreiner E; University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, 4102, Australia.
  • Chesi A; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK.
  • Zemel BS; Department of Computer Science and Biomedical Informatics of the University of Thessaly, Lamia, GR 35100, Greece.
  • Bønnelykke K; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, 45110, Greece.
  • Boer CG; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, 2820, Denmark.
  • Ahluwalia TS; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
  • Bisgaard H; Division of GI, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
  • Evangelou E; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Heppe DHM; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, 2820, Denmark.
  • Bonewald LF; Department of Internal Medicine, Erasmus MC University, Rotterdam, 3015GE, The Netherlands.
  • Gorski JP; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, 2820, Denmark.
  • Ghanbari M; Steno Diabetes Center Copenhagen, Gentofte, 2820, Denmark.
  • Demissie S; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, 2820, Denmark.
  • Duque G; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, 45110, Greece.
  • Maurano MT; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK.
  • Kiel DP; The Generation R Study Group, Erasmus Medical Center, Rotterdam, 3015GE, The Netherlands.
  • Hsu YH; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015GE, The Netherlands.
  • C J van der Eerden B; Departments of Anatomy and Cell Biology and Orthopaedic Surgery, School of Medicine, Indiana University, Indianapolis, IN, 46202, USA.
  • Ackert-Bicknell C; Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, MO, 64108, USA.
  • Reppe S; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015GE, The Netherlands.
  • Gautvik KM; Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad,, Iran.
  • Raastad T; Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02131, USA.
  • Karasik D; Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, St Albans, Victoria, 3021, Australia.
  • van de Peppel J; Institute for Systems Genetics, New York University Langone Medical Center, New York, NY, 10016, USA.
  • Jaddoe VWV; Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.
  • Uitterlinden AG; Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.
  • Tobias JH; Broad Institute of MIT and Harvard, Boston, MA, 02115, USA.
  • Grant SFA; Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.
  • Bagos PG; Broad Institute of MIT and Harvard, Boston, MA, 02115, USA.
  • Evans DM; Molecular and Integrative Physiological Sciences, Harvard School of Public Health, Boston, MA, 02115, USA.
  • Rivadeneira F; Department of Internal Medicine, Erasmus MC University, Rotterdam, 3015GE, The Netherlands.
Nat Commun ; 8(1): 121, 2017 07 25.
Article en En | MEDLINE | ID: mdl-28743860
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Portadoras / Metaanálisis como Asunto / Desarrollo Musculoesquelético / Proteína 1 de Unión a los Elementos Reguladores de Esteroles / Estudio de Asociación del Genoma Completo / Pleiotropía Genética Tipo de estudio: Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Child / Female / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2017 Tipo del documento: Article País de afiliación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Portadoras / Metaanálisis como Asunto / Desarrollo Musculoesquelético / Proteína 1 de Unión a los Elementos Reguladores de Esteroles / Estudio de Asociación del Genoma Completo / Pleiotropía Genética Tipo de estudio: Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Child / Female / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2017 Tipo del documento: Article País de afiliación: Países Bajos