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Malignancy in Pediatric-onset Systemic Lupus Erythematosus.
Bernatsky, Sasha; Clarke, Ann E; Zahedi Niaki, Omid; Labrecque, Jeremy; Schanberg, Laura E; Silverman, Earl D; Hayward, Kristen; Imundo, Lisa; Brunner, Hermine I; Haines, Kathleen A; Cron, Randy Q; Oen, Kiem; Wagner-Weiner, Linda; Rosenberg, Alan M; O'Neil, Kathleen M; Duffy, Ciarán M; von Scheven, Emily; Joseph, Lawrence; Lee, Jennifer L; Ramsey-Goldman, Rosalind.
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  • Bernatsky S; From the Research Institute of the McGill University Health Centre, Montreal, Quebec; University of Calgary, Calgary, Alberta; The Hospital for Sick Children, Hospital for Sick Children Research Institute, University of Toronto, Toronto; Children's Hospital of Eastern Ontario, Ottawa, Ontario; Unive
  • Clarke AE; S. Bernatsky, MD, PhD, Research Institute of the McGill University Health Centre; A.E. Clarke, MD, MSc, University of Calgary; O. Zahedi Niaki, MD, Research Institute of the McGill University Health Centre; J. Labrecque, MSc, Research Institute of the McGill University Health Centre; L.E. Schanberg,
  • Zahedi Niaki O; From the Research Institute of the McGill University Health Centre, Montreal, Quebec; University of Calgary, Calgary, Alberta; The Hospital for Sick Children, Hospital for Sick Children Research Institute, University of Toronto, Toronto; Children's Hospital of Eastern Ontario, Ottawa, Ontario; Unive
  • Labrecque J; S. Bernatsky, MD, PhD, Research Institute of the McGill University Health Centre; A.E. Clarke, MD, MSc, University of Calgary; O. Zahedi Niaki, MD, Research Institute of the McGill University Health Centre; J. Labrecque, MSc, Research Institute of the McGill University Health Centre; L.E. Schanberg,
  • Schanberg LE; From the Research Institute of the McGill University Health Centre, Montreal, Quebec; University of Calgary, Calgary, Alberta; The Hospital for Sick Children, Hospital for Sick Children Research Institute, University of Toronto, Toronto; Children's Hospital of Eastern Ontario, Ottawa, Ontario; Unive
  • Silverman ED; S. Bernatsky, MD, PhD, Research Institute of the McGill University Health Centre; A.E. Clarke, MD, MSc, University of Calgary; O. Zahedi Niaki, MD, Research Institute of the McGill University Health Centre; J. Labrecque, MSc, Research Institute of the McGill University Health Centre; L.E. Schanberg,
  • Hayward K; From the Research Institute of the McGill University Health Centre, Montreal, Quebec; University of Calgary, Calgary, Alberta; The Hospital for Sick Children, Hospital for Sick Children Research Institute, University of Toronto, Toronto; Children's Hospital of Eastern Ontario, Ottawa, Ontario; Unive
  • Imundo L; S. Bernatsky, MD, PhD, Research Institute of the McGill University Health Centre; A.E. Clarke, MD, MSc, University of Calgary; O. Zahedi Niaki, MD, Research Institute of the McGill University Health Centre; J. Labrecque, MSc, Research Institute of the McGill University Health Centre; L.E. Schanberg,
  • Brunner HI; From the Research Institute of the McGill University Health Centre, Montreal, Quebec; University of Calgary, Calgary, Alberta; The Hospital for Sick Children, Hospital for Sick Children Research Institute, University of Toronto, Toronto; Children's Hospital of Eastern Ontario, Ottawa, Ontario; Unive
  • Haines KA; S. Bernatsky, MD, PhD, Research Institute of the McGill University Health Centre; A.E. Clarke, MD, MSc, University of Calgary; O. Zahedi Niaki, MD, Research Institute of the McGill University Health Centre; J. Labrecque, MSc, Research Institute of the McGill University Health Centre; L.E. Schanberg,
  • Cron RQ; From the Research Institute of the McGill University Health Centre, Montreal, Quebec; University of Calgary, Calgary, Alberta; The Hospital for Sick Children, Hospital for Sick Children Research Institute, University of Toronto, Toronto; Children's Hospital of Eastern Ontario, Ottawa, Ontario; Unive
  • Oen K; S. Bernatsky, MD, PhD, Research Institute of the McGill University Health Centre; A.E. Clarke, MD, MSc, University of Calgary; O. Zahedi Niaki, MD, Research Institute of the McGill University Health Centre; J. Labrecque, MSc, Research Institute of the McGill University Health Centre; L.E. Schanberg,
  • Wagner-Weiner L; From the Research Institute of the McGill University Health Centre, Montreal, Quebec; University of Calgary, Calgary, Alberta; The Hospital for Sick Children, Hospital for Sick Children Research Institute, University of Toronto, Toronto; Children's Hospital of Eastern Ontario, Ottawa, Ontario; Unive
  • Rosenberg AM; S. Bernatsky, MD, PhD, Research Institute of the McGill University Health Centre; A.E. Clarke, MD, MSc, University of Calgary; O. Zahedi Niaki, MD, Research Institute of the McGill University Health Centre; J. Labrecque, MSc, Research Institute of the McGill University Health Centre; L.E. Schanberg,
  • O'Neil KM; From the Research Institute of the McGill University Health Centre, Montreal, Quebec; University of Calgary, Calgary, Alberta; The Hospital for Sick Children, Hospital for Sick Children Research Institute, University of Toronto, Toronto; Children's Hospital of Eastern Ontario, Ottawa, Ontario; Unive
  • Duffy CM; S. Bernatsky, MD, PhD, Research Institute of the McGill University Health Centre; A.E. Clarke, MD, MSc, University of Calgary; O. Zahedi Niaki, MD, Research Institute of the McGill University Health Centre; J. Labrecque, MSc, Research Institute of the McGill University Health Centre; L.E. Schanberg,
  • von Scheven E; From the Research Institute of the McGill University Health Centre, Montreal, Quebec; University of Calgary, Calgary, Alberta; The Hospital for Sick Children, Hospital for Sick Children Research Institute, University of Toronto, Toronto; Children's Hospital of Eastern Ontario, Ottawa, Ontario; Unive
  • Joseph L; S. Bernatsky, MD, PhD, Research Institute of the McGill University Health Centre; A.E. Clarke, MD, MSc, University of Calgary; O. Zahedi Niaki, MD, Research Institute of the McGill University Health Centre; J. Labrecque, MSc, Research Institute of the McGill University Health Centre; L.E. Schanberg,
  • Lee JL; From the Research Institute of the McGill University Health Centre, Montreal, Quebec; University of Calgary, Calgary, Alberta; The Hospital for Sick Children, Hospital for Sick Children Research Institute, University of Toronto, Toronto; Children's Hospital of Eastern Ontario, Ottawa, Ontario; Unive
  • Ramsey-Goldman R; S. Bernatsky, MD, PhD, Research Institute of the McGill University Health Centre; A.E. Clarke, MD, MSc, University of Calgary; O. Zahedi Niaki, MD, Research Institute of the McGill University Health Centre; J. Labrecque, MSc, Research Institute of the McGill University Health Centre; L.E. Schanberg,
J Rheumatol ; 44(10): 1484-1486, 2017 Oct.
Article en En | MEDLINE | ID: mdl-28765255
OBJECTIVE: To determine cancer incidence in a large pediatric-onset systemic lupus erythematosus (SLE) population. METHODS: Data were examined from 12 pediatric SLE registries in North America. Patients were linked to their regional cancer registries to detect cancers observed after cohort entry, defined as date first seen in the clinic. The expected number of malignancies was obtained by multiplying the person-years in the cohort (defined from cohort entry to end of followup) by the geographically matched age-, sex-, and calendar year-specific cancer rates. The standardized incidence ratio (SIR; ratio of cancers observed to expected) was generated, with 95% CI. RESULTS: A total of 1168 patients were identified from the registries. The mean age at cohort entry was 13 years (SD 3.3), and 83.7% of the subjects were female. The mean duration of followup was 7.6 years, resulting in a total observation period of 8839 years spanning the calendar period 1974-2009. During followup, fourteen invasive cancers occurred (1.6 cancers per 1000 person-yrs, SIR 4.13, 95% CI 2.26-6.93). Three of these were hematologic (all lymphomas), resulting in an SIR for hematologic cancers of 4.68 (95% CI 0.96-13.67). SIR were increased for both male and female patients, and across age groups. CONCLUSION: Although cancer remains a relatively rare outcome in pediatric-onset SLE, our data do suggest an increase in cancer for patients followed an average of 7.6 years. About one-fifth of the cancers were hematologic. Longer followup, and study of drug effects and disease activity, is warranted.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Lupus Eritematoso Sistémico / Neoplasias Tipo de estudio: Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: J Rheumatol Año: 2017 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Lupus Eritematoso Sistémico / Neoplasias Tipo de estudio: Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: J Rheumatol Año: 2017 Tipo del documento: Article