Human leucocyte antigen (HLA-DR) gene expression is reduced in sepsis and correlates with impaired TNF&#945; response: A diagnostic tool for immunosuppression?

Winkler, Martin Sebastian; Rissiek, Anne; Priefler, Marion; Schwedhelm, Edzard; Robbe, Linda; Bauer, Antonia; Zahrte, Corinne; Zoellner, Christian; Kluge, Stefan; Nierhaus, Axel

Human leucocyte antigen (HLA-DR) gene expression is reduced in sepsis and correlates with impaired TNFα response: A diagnostic tool for immunosuppression?

Winkler, Martin Sebastian; Rissiek, Anne; Priefler, Marion; Schwedhelm, Edzard; Robbe, Linda; Bauer, Antonia; Zahrte, Corinne; Zoellner, Christian; Kluge, Stefan; Nierhaus, Axel.

Afiliación

Winkler MS; Department of Anaesthesiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Rissiek A; Department of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Priefler M; Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Schwedhelm E; Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Robbe L; Department of Anaesthesiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Bauer A; Department of Anaesthesiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Zahrte C; Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Zoellner C; Department of Anaesthesiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Kluge S; Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Nierhaus A; Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

PLoS One ; 12(8): e0182427, 2017.

Article en En | MEDLINE | ID: mdl-28771573

Asunto(s)

Biomarcadores/metabolismo; Cadenas alfa de HLA-DR/metabolismo; Tolerancia Inmunológica/inmunología; Monocitos/inmunología; Sepsis/diagnóstico; Sepsis/inmunología; Factor de Necrosis Tumoral alfa/farmacología; Anciano; Estudios de Casos y Controles; Femenino; Humanos; Terapia de Inmunosupresión; Lipopolisacáridos/farmacología; Masculino; Persona de Mediana Edad; Monocitos/efectos de los fármacos; Monocitos/metabolismo; Estudios Prospectivos; Sepsis/tratamiento farmacológico; Sepsis/metabolismo

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Monocitos / Biomarcadores / Factor de Necrosis Tumoral alfa / Sepsis / Cadenas alfa de HLA-DR / Tolerancia Inmunológica Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2017 Tipo del documento: Article País de afiliación: Alemania

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