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Semiquantitative Assessment of 18F-FDG Uptake in the Normal Skeleton: Comparison Between PET/CT and Time-of-Flight Simultaneous PET/MRI.
Minamimoto, Ryogo; Xu, Guofan; Jamali, Mehran; Holley, Dawn; Barkhodari, Amir; Zaharchuk, Greg; Iagaru, Andrei.
Afiliación
  • Minamimoto R; 1 Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, 300 Pasteur Dr, Rm H-2200, Stanford University, Stanford, CA 94305-5281.
  • Xu G; 2 Molecular Imaging Program at Stanford, Department of Radiology, Stanford University, Stanford, CA.
  • Jamali M; 1 Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, 300 Pasteur Dr, Rm H-2200, Stanford University, Stanford, CA 94305-5281.
  • Holley D; 1 Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, 300 Pasteur Dr, Rm H-2200, Stanford University, Stanford, CA 94305-5281.
  • Barkhodari A; 2 Molecular Imaging Program at Stanford, Department of Radiology, Stanford University, Stanford, CA.
  • Zaharchuk G; 3 Department of Radiology, Stanford University, Stanford, CA.
  • Iagaru A; 1 Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, 300 Pasteur Dr, Rm H-2200, Stanford University, Stanford, CA 94305-5281.
AJR Am J Roentgenol ; 209(5): 1136-1142, 2017 Nov.
Article en En | MEDLINE | ID: mdl-28777652
ABSTRACT

OBJECTIVE:

Differences in the attenuation correction methods used in PET/CT scanners versus the newly introduced whole-body simultaneous PET/MRI reportedly result in differences in standardized uptake values (SUVs) in the normal skeleton. The aim of the study was to compare the semiquantitative FDG uptake in the normal skeleton using time-of-flight (TOF) PET/MRI versus PET/CT with and without TOF. SUBJECTS AND

METHODS:

Participants received a single FDG injection and underwent non-TOF and TOF PET/CT (n = 23) or non-TOF PET/CT and TOF PET/MRI (n = 50). Mean SUV (SUVmean) and maximum SUV (SUVmax) were measured from all PET scans for nine normal regions of the skeleton. Pearson correlation coefficients (r) were used to evaluate the SUVmax and SUVmean of normal skeleton between non-TOF and TOF PET/CT, as well as between non-TOF PET/CT and TOF PET/MRI. In addition, percentage differences in SUVmax and SUVmean of the normal skeleton between non-TOF and TOF PET/CT and between non-TOF PET/CT and TOF PET/MRI were evaluated.

RESULTS:

The SUVmax and SUVmean in the normal skeleton significantly increased between non-TOF and TOF PET/CT, but they significantly decreased between non-TOF PET/CT and TOF PET/MRI. The SUVmax and SUVmean in normal skeleton showed good correlation between non-TOF PET/CT and TOF PET/MRI (SUVmax, r = 0.88; SUVmean, r = 0.91) and showed a similar trend between non-TOF and TOF PET/CT (SUVmax, r = 0.88; SUVmean, r = 0.94).

CONCLUSION:

In the normal skeleton, SUVmax and SUVmean showed high correlations between PET/MRI and PET/CT. The MRI attenuation correction used in TOF PET/MRI provides reliable semiquantitative measurements in the normal skeleton.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Huesos / Imagen por Resonancia Magnética / Radiofármacos / Fluorodesoxiglucosa F18 / Tomografía Computarizada por Tomografía de Emisión de Positrones Tipo de estudio: Observational_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: AJR Am J Roentgenol Año: 2017 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Huesos / Imagen por Resonancia Magnética / Radiofármacos / Fluorodesoxiglucosa F18 / Tomografía Computarizada por Tomografía de Emisión de Positrones Tipo de estudio: Observational_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: AJR Am J Roentgenol Año: 2017 Tipo del documento: Article