Chaperonin GroEL accelerates protofibril formation and decorates fibrils of the Het-s prion protein.

Wälti, Marielle A; Schmidt, Thomas; Murray, Dylan T; Wang, Huaibin; Hinshaw, Jenny E; Clore, G Marius

Wälti, Marielle A; Schmidt, Thomas; Murray, Dylan T; Wang, Huaibin; Hinshaw, Jenny E; Clore, G Marius.

Afiliación

Wälti MA; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520.
Schmidt T; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520.
Murray DT; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520.
Wang H; Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0820.
Hinshaw JE; Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0820.
Clore GM; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520; mariusc@intra.niddk.nih.gov.

Proc Natl Acad Sci U S A ; 114(34): 9104-9109, 2017 08 22.

Article en En | MEDLINE | ID: mdl-28784759

Asunto(s)

Amiloide/química; Chaperonina 60/química; Proteínas Fúngicas/química; Proteínas Priónicas/química; Secuencia de Aminoácidos; Amiloide/metabolismo; Amiloide/ultraestructura; Chaperonina 10/química; Chaperonina 10/genética; Chaperonina 10/metabolismo; Chaperonina 60/genética; Chaperonina 60/metabolismo; Espectroscopía de Resonancia por Spin del Electrón; Proteínas Fúngicas/genética; Proteínas Fúngicas/metabolismo; Espectroscopía de Resonancia Magnética; Microscopía de Fuerza Atómica; Microscopía Electrónica; Modelos Moleculares; Mutación; Proteínas Priónicas/genética; Proteínas Priónicas/metabolismo; Unión Proteica; Conformación Proteica

Palabras clave

EPR; NMR; amyloidchaperone interactions; atomic force microscopy; electron microscopy

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Fúngicas / Chaperonina 60 / Proteínas Priónicas / Amiloide Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2017 Tipo del documento: Article

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