Secreted products of Fasciola hepatica inhibit the induction of T cell responses that mediate allergy.
Parasite Immunol
; 39(10)2017 Oct.
Article
en En
| MEDLINE
| ID: mdl-28815724
There is evidence from epidemiology studies of a negative association between infection with helminth parasites and the development of allergy and asthma. Here, we demonstrate that the excretory/secretory products of the helminth Fasciola hepatica (FHES) protected mice against ovalbumin (OVA)-induced allergic asthma when administered at time of allergen sensitization. FHES reduced the accumulation of mucus, eosinophils and lymphocytes into the airways of allergen-challenged mice. Furthermore, FHES treatment suppressed Th2 responses in the airways. Interestingly, systemic administration of FHES at allergen challenge had no effect on airway inflammation, demonstrating that alum-induced Th2 response is set following initial allergen sensitization. Our findings highlight the immunomodulatory potential of molecules secreted by F. hepatica.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Asma
/
Proteínas del Helminto
/
Células Th2
/
Fasciola hepatica
/
Factores Inmunológicos
Límite:
Animals
Idioma:
En
Revista:
Parasite Immunol
Año:
2017
Tipo del documento:
Article
País de afiliación:
Irlanda