Mutations in the promoter of the telomerase gene <i>TERT</i> contribute to tumorigenesis by a two-step mechanism.

Chiba, Kunitoshi; Lorbeer, Franziska K; Shain, A Hunter; McSwiggen, David T; Schruf, Eva; Oh, Areum; Ryu, Jekwan; Darzacq, Xavier; Bastian, Boris C; Hockemeyer, Dirk

Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism.

Chiba, Kunitoshi; Lorbeer, Franziska K; Shain, A Hunter; McSwiggen, David T; Schruf, Eva; Oh, Areum; Ryu, Jekwan; Darzacq, Xavier; Bastian, Boris C; Hockemeyer, Dirk.

Afiliación

Chiba K; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Lorbeer FK; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Shain AH; Departments of Dermatology and Pathology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94115, USA.
McSwiggen DT; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Schruf E; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Oh A; Optical Biosystems, Santa Clara, CA 95050, USA.
Ryu J; Optical Biosystems, Santa Clara, CA 95050, USA.
Darzacq X; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Bastian BC; Departments of Dermatology and Pathology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94115, USA.
Hockemeyer D; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. hockemeyer@berkeley.edu.

Science ; 357(6358): 1416-1420, 2017 09 29.

Article en En | MEDLINE | ID: mdl-28818973

Asunto(s)

Carcinogénesis/genética; Inestabilidad Genómica/genética; Melanoma/genética; Regiones Promotoras Genéticas/genética; Neoplasias Cutáneas/genética; Telomerasa/genética; Células Cultivadas; Humanos; Mutación; Telómero; Acortamiento del Telómero

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Regiones Promotoras Genéticas / Telomerasa / Inestabilidad Genómica / Carcinogénesis / Melanoma Límite: Humans Idioma: En Revista: Science Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos

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