Anthranilate phosphoribosyltransferase: Binding determinants for 5'-phospho-alpha-d-ribosyl-1'-pyrophosphate (PRPP) and the implications for inhibitor design.

Evans, Genevieve L; Furkert, Daniel P; Abermil, Nacim; Kundu, Preeti; de Lange, Katrina M; Parker, Emily J; Brimble, Margaret A; Baker, Edward N; Lott, J Shaun

Evans, Genevieve L; Furkert, Daniel P; Abermil, Nacim; Kundu, Preeti; de Lange, Katrina M; Parker, Emily J; Brimble, Margaret A; Baker, Edward N; Lott, J Shaun.

Afiliación

Evans GL; Maurice Wilkins Centre for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, 3A Symonds Street, Auckland 1142, New Zealand; School of Biological Sciences, University of Auckland, 3 Symonds Street, Auckland 1142, New Zealand. Electronic address: g.evans@auckland.ac.nz.
Furkert DP; Maurice Wilkins Centre for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, 3A Symonds Street, Auckland 1142, New Zealand; School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland 1142, New Zealand.
Abermil N; Maurice Wilkins Centre for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, 3A Symonds Street, Auckland 1142, New Zealand; School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland 1142, New Zealand.
Kundu P; Maurice Wilkins Centre for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, 3A Symonds Street, Auckland 1142, New Zealand; Biomolecular Interaction Centre, University of Canterbury, P. O. Box 4800, Christchurch 8140, New Zealand; Department of Chemistry, University o
de Lange KM; Maurice Wilkins Centre for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, 3A Symonds Street, Auckland 1142, New Zealand; School of Biological Sciences, University of Auckland, 3 Symonds Street, Auckland 1142, New Zealand.
Parker EJ; Maurice Wilkins Centre for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, 3A Symonds Street, Auckland 1142, New Zealand; Biomolecular Interaction Centre, University of Canterbury, P. O. Box 4800, Christchurch 8140, New Zealand; Department of Chemistry, University o
Brimble MA; Maurice Wilkins Centre for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, 3A Symonds Street, Auckland 1142, New Zealand; School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland 1142, New Zealand.
Baker EN; Maurice Wilkins Centre for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, 3A Symonds Street, Auckland 1142, New Zealand; School of Biological Sciences, University of Auckland, 3 Symonds Street, Auckland 1142, New Zealand.
Lott JS; Maurice Wilkins Centre for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, 3A Symonds Street, Auckland 1142, New Zealand; School of Biological Sciences, University of Auckland, 3 Symonds Street, Auckland 1142, New Zealand. Electronic address: s.lott@auckland.ac.nz.

Biochim Biophys Acta Proteins Proteom ; 1866(2): 264-274, 2018 Feb.

Article en En | MEDLINE | ID: mdl-28844746

Asunto(s)

Antranilato Fosforribosiltransferasa/química; Proteínas Bacterianas/química; Mycobacterium tuberculosis/enzimología; Sitios de Unión; Cristalografía por Rayos X; Estructura Secundaria de Proteína

Palabras clave

Metal catalyzed transferases; Mg(2+) chelated substrates; PRT inhibitors; Phosphonate inhibitors; Phosphoribosylpyrophosphate; Phosphoribosyltransferase

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Antranilato Fosforribosiltransferasa / Mycobacterium tuberculosis Idioma: En Revista: Biochim Biophys Acta Proteins Proteom Año: 2018 Tipo del documento: Article

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