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Mapping White Matter Microstructure in the One Month Human Brain.
Dean, D C; Planalp, E M; Wooten, W; Adluru, N; Kecskemeti, S R; Frye, C; Schmidt, C K; Schmidt, N L; Styner, M A; Goldsmith, H H; Davidson, R J; Alexander, A L.
Afiliación
  • Dean DC; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA. deaniii@wisc.edu.
  • Planalp EM; Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA. deaniii@wisc.edu.
  • Wooten W; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.
  • Adluru N; Department of Psychology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
  • Kecskemeti SR; Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA.
  • Frye C; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.
  • Schmidt CK; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.
  • Schmidt NL; Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA.
  • Styner MA; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.
  • Goldsmith HH; Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA.
  • Davidson RJ; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.
  • Alexander AL; Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA.
Sci Rep ; 7(1): 9759, 2017 08 29.
Article en En | MEDLINE | ID: mdl-28852074
White matter microstructure, essential for efficient and coordinated transmission of neural communications, undergoes pronounced development during the first years of life, while deviations to this neurodevelopmental trajectory likely result in alterations of brain connectivity relevant to behavior. Hence, systematic evaluation of white matter microstructure in the normative brain is critical for a neuroscientific approach to both typical and atypical early behavioral development. However, few studies have examined the infant brain in detail, particularly in infants under 3 months of age. Here, we utilize quantitative techniques of diffusion tensor imaging and neurite orientation dispersion and density imaging to investigate neonatal white matter microstructure in 104 infants. An optimized multiple b-value diffusion protocol was developed to allow for successful acquisition during non-sedated sleep. Associations between white matter microstructure measures and gestation corrected age, regional asymmetries, infant sex, as well as newborn growth measures were assessed. Results highlight changes of white matter microstructure during the earliest periods of development and demonstrate differential timing of developing regions and regional asymmetries. Our results contribute to a growing body of research investigating the neurobiological changes associated with neurodevelopment and suggest that characteristics of white matter microstructure are already underway in the weeks immediately following birth.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Desarrollo Infantil / Organogénesis / Sustancia Blanca Límite: Female / Humans / Infant / Male / Newborn Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Desarrollo Infantil / Organogénesis / Sustancia Blanca Límite: Female / Humans / Infant / Male / Newborn Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos