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A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity.
Kuepfer, Lars; Clayton, Olivia; Thiel, Christoph; Cordes, Henrik; Nudischer, Ramona; Blank, Lars M; Baier, Vanessa; Heymans, Stephane; Caiment, Florian; Roth, Adrian; Fluri, David A; Kelm, Jens M; Castell, José; Selevsek, Nathalie; Schlapbach, Ralph; Keun, Hector; Hynes, James; Sarkans, Ugis; Gmuender, Hans; Herwig, Ralf; Niederer, Steven; Schuchhardt, Johannes; Segall, Matthew; Kleinjans, Jos.
Afiliación
  • Kuepfer L; Institute of Applied Microbiology, RWTH, Aachen, Germany. lars.kuepfer@rwth-aachen.de.
  • Clayton O; Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland.
  • Thiel C; Institute of Applied Microbiology, RWTH, Aachen, Germany.
  • Cordes H; Institute of Applied Microbiology, RWTH, Aachen, Germany.
  • Nudischer R; Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland.
  • Blank LM; Institute of Applied Microbiology, RWTH, Aachen, Germany.
  • Baier V; Institute of Applied Microbiology, RWTH, Aachen, Germany.
  • Heymans S; Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, Netherlands.
  • Caiment F; Department of Cardiovascular Sciences, Leuven University, Leuven, Belgium.
  • Roth A; Department of Toxicogenomics, Maastricht University, Maastricht, Netherlands.
  • Fluri DA; Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland.
  • Kelm JM; InSphero AG, Schlieren, Switzerland.
  • Castell J; InSphero AG, Schlieren, Switzerland.
  • Selevsek N; Instituto de Investigación Sanitaria. Hospital Universitario La Fe, Valencia, Spain.
  • Schlapbach R; Functional Genomics Center Zurich, ETH Zurich and University of Zurich, Zurich, Switzerland.
  • Keun H; Functional Genomics Center Zurich, ETH Zurich and University of Zurich, Zurich, Switzerland.
  • Hynes J; Division of Cancer, Department of Surgery and Cancer, Imperial College London, London, UK.
  • Sarkans U; Luxcel Biosciences Ltd, Cork, Ireland.
  • Gmuender H; European Molecular Biology Laboratory, Cambridge, UK.
  • Herwig R; Genedata AG, Basel, Switzerland.
  • Niederer S; Department Computational Molecular Biology, Max-Planck-Institute for Molecular Genetics, Berlin, Germany.
  • Schuchhardt J; Department of Imaging Sciences and BioMedical Engineering, King's College London, London, UK.
  • Segall M; Microdiscovery GmbH, Berlin, Germany.
  • Kleinjans J; Optibrium Ltd, Cambridge, UK.
Arch Toxicol ; 92(1): 553-555, 2018 Jan.
Article en En | MEDLINE | ID: mdl-28852801
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Técnicas de Cultivo de Órganos / Pruebas de Toxicidad Aguda / Evaluación Preclínica de Medicamentos / Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos Límite: Animals / Humans Idioma: En Revista: Arch Toxicol Año: 2018 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Técnicas de Cultivo de Órganos / Pruebas de Toxicidad Aguda / Evaluación Preclínica de Medicamentos / Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos Límite: Animals / Humans Idioma: En Revista: Arch Toxicol Año: 2018 Tipo del documento: Article País de afiliación: Alemania