Insulin upregulates GRIM-19 and protects cardiac mitochondrial morphology in type 1 diabetic rats partly through PI3K/AKT signaling pathway.

Li, Yong-Guang; Dong, Zhi-Feng; Chen, Kan-Kai; He, Ya-Ping; Dai, Xiao-Yan; Li, Shuai; Li, Jing-Bo; Zhu, Wei; Wei, Meng

Li, Yong-Guang; Dong, Zhi-Feng; Chen, Kan-Kai; He, Ya-Ping; Dai, Xiao-Yan; Li, Shuai; Li, Jing-Bo; Zhu, Wei; Wei, Meng.

Afiliación

Li YG; Department of Cardiovascular Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, PR China. Electronic address: liyongguang222326@163.com.
Dong ZF; Department of Cardiovascular Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, PR China.
Chen KK; Department of Cardiovascular Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, PR China.
He YP; Department of Cardiovascular Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, PR China.
Dai XY; Department of Cardiovascular Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, PR China.
Li S; Department of Cardiovascular Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, PR China.
Li JB; Department of Cardiovascular Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, PR China.
Zhu W; Department of Cardiovascular Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, PR China.
Wei M; Department of Cardiovascular Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, PR China. Electronic address: weimeng_sjtu6h@163.com.

Biochem Biophys Res Commun ; 493(1): 611-617, 2017 11 04.

Article en En | MEDLINE | ID: mdl-28867181

Asunto(s)

Diabetes Mellitus Tipo 1/metabolismo; Diabetes Mellitus Tipo 1/patología; Complejo I de Transporte de Electrón/metabolismo; Insulina/administración & dosificación; Mitocondrias Cardíacas/patología; Chaperonas Moleculares/metabolismo; Fosfatidilinositol 3-Quinasas/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Animales; Células HeLa; Humanos; Masculino; Mitocondrias Cardíacas/efectos de los fármacos; Mitocondrias Cardíacas/metabolismo; Ratas; Ratas Sprague-Dawley; Transducción de Señal/efectos de los fármacos; Estreptozocina; Regulación hacia Arriba/efectos de los fármacos

Palabras clave

Heart; Insulin; Mitochondria; Retinoic-interferon-induced mortality 19; Type 1 diabetes

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Chaperonas Moleculares / Fosfatidilinositol 3-Quinasas / Complejo I de Transporte de Electrón / Diabetes Mellitus Tipo 1 / Proteínas Proto-Oncogénicas c-akt / Insulina / Mitocondrias Cardíacas Límite: Animals / Humans / Male Idioma: En Revista: Biochem Biophys Res Commun Año: 2017 Tipo del documento: Article

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