Molecular Evolution of Antifungal Drug Resistance.
Annu Rev Microbiol
; 71: 753-775, 2017 09 08.
Article
en En
| MEDLINE
| ID: mdl-28886681
ABSTRACT
The fungal pathogens Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus have transitioned from a rare curiosity to a leading cause of human mortality. The management of infections caused by these organisms is intimately dependent on the efficacy of antifungal agents; however, fungi that are resistant to these treatments are regularly isolated in the clinic, impeding our ability to control infections. Given the significant impact fungal pathogens have on human health, it is imperative to understand the molecular mechanisms that govern antifungal drug resistance. This review describes our current knowledge of the mechanisms by which antifungal drug resistance evolves in experimental populations and clinical settings. We explore current antifungal treatment options and discuss promising strategies to impede the evolution of drug resistance. By tackling antifungal drug resistance as an evolutionary problem, there is potential to improve the utility of current treatments and accelerate the development of novel therapeutic strategies.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Aspergillus fumigatus
/
Candida albicans
/
Evolución Molecular
/
Cryptococcus neoformans
/
Farmacorresistencia Fúngica
/
Antifúngicos
Límite:
Humans
Idioma:
En
Revista:
Annu Rev Microbiol
Año:
2017
Tipo del documento:
Article