XIAP over-expression is an independent poor prognostic marker in Middle Eastern breast cancer and can be targeted to induce efficient apoptosis.

Hussain, Azhar R; Siraj, Abdul Khalid; Ahmed, Maqbool; Bu, Rong; Pratheeshkumar, Poyil; Alrashed, Alanood M; Qadri, Zeeshan; Ajarim, Dahish; Al-Dayel, Fouad; Beg, Shaham; Al-Kuraya, Khawla S

Hussain, Azhar R; Siraj, Abdul Khalid; Ahmed, Maqbool; Bu, Rong; Pratheeshkumar, Poyil; Alrashed, Alanood M; Qadri, Zeeshan; Ajarim, Dahish; Al-Dayel, Fouad; Beg, Shaham; Al-Kuraya, Khawla S.

Afiliación

Hussain AR; Human Cancer Genomic Research, King Faisal Specialist Hospital and Research Cancer, MBC#98-16, P.O. Box 3354, Riyadh, 11211, Saudi Arabia.
Siraj AK; Human Cancer Genomic Research, King Faisal Specialist Hospital and Research Cancer, MBC#98-16, P.O. Box 3354, Riyadh, 11211, Saudi Arabia.
Ahmed M; Human Cancer Genomic Research, King Faisal Specialist Hospital and Research Cancer, MBC#98-16, P.O. Box 3354, Riyadh, 11211, Saudi Arabia.
Bu R; Human Cancer Genomic Research, King Faisal Specialist Hospital and Research Cancer, MBC#98-16, P.O. Box 3354, Riyadh, 11211, Saudi Arabia.
Pratheeshkumar P; Human Cancer Genomic Research, King Faisal Specialist Hospital and Research Cancer, MBC#98-16, P.O. Box 3354, Riyadh, 11211, Saudi Arabia.
Alrashed AM; AlFaisal University, Riyadh, Saudi Arabia.
Qadri Z; Human Cancer Genomic Research, King Faisal Specialist Hospital and Research Cancer, MBC#98-16, P.O. Box 3354, Riyadh, 11211, Saudi Arabia.
Ajarim D; Oncology Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Al-Dayel F; Department of Pathology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Beg S; Human Cancer Genomic Research, King Faisal Specialist Hospital and Research Cancer, MBC#98-16, P.O. Box 3354, Riyadh, 11211, Saudi Arabia.
Al-Kuraya KS; Human Cancer Genomic Research, King Faisal Specialist Hospital and Research Cancer, MBC#98-16, P.O. Box 3354, Riyadh, 11211, Saudi Arabia. kkuraya@kfshrc.edu.sa.

BMC Cancer ; 17(1): 640, 2017 Sep 11.

Article en En | MEDLINE | ID: mdl-28893228

Asunto(s)

Fosfatidilinositol 3-Quinasas/genética; Pronóstico; Neoplasias de la Mama Triple Negativas/tratamiento farmacológico; Proteína Inhibidora de la Apoptosis Ligada a X/genética; Adulto; Anciano; Animales; Apoptosis/efectos de los fármacos; Benzoquinonas/administración & dosificación; Biomarcadores de Tumor/genética; Cromonas/administración & dosificación; Femenino; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Humanos; Ratones; Persona de Mediana Edad; Morfolinas/administración & dosificación; Inhibidores de las Quinasa Fosfoinosítidos-3; Transducción de Señal/efectos de los fármacos; Neoplasias de la Mama Triple Negativas/genética; Neoplasias de la Mama Triple Negativas/patología; Proteína Inhibidora de la Apoptosis Ligada a X/antagonistas & inhibidores; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

Apoptosis; Breast cancer; Embelin; P-AKT; XIAP

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pronóstico / Fosfatidilinositol 3-Quinasas / Proteína Inhibidora de la Apoptosis Ligada a X / Neoplasias de la Mama Triple Negativas Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Animals / Female / Humans / Middle aged Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2017 Tipo del documento: Article País de afiliación: Arabia Saudita

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