Circulating cytokines and small molecules follow distinct expression patterns in acute myeloid leukaemia.
Br J Cancer
; 117(10): 1551-1556, 2017 Nov 07.
Article
en En
| MEDLINE
| ID: mdl-28898234
ABSTRACT
BACKGROUND:
Although aberrant expression of cytokines and small molecules (analytes) is well documented in acute myeloid leukaemia (AML), their co-expression patterns are not yet identified. In addition, plasma baselines for some analytes that are biomarkers for other cancers have not been previously reported in AML.METHODS:
We used multiplex array technology to simultaneously detect and quantify 32 plasma analyte (22 reported analytes and 10 novel analytes) levels in 38 patients.RESULTS:
In our study, 16 analytes are found to be significantly deregulated (13 higher, 3 lower, Mann-Whitney U-test, P-value <0.005), where 5 of them have never been reported before in AML. We predicted a seven-analyte-containing multiplex panel for diagnosis of AML and, among them, MIF could be a possible therapeutic target. In addition, we observed that circulating analytes show five co-expression signatures.CONCLUSIONS:
Circulating analyte expression in AML significantly differs from normal, and follow distinct expression patterns.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Leucemia Mieloide Aguda
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Biomarcadores de Tumor
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Citocinas
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Br J Cancer
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos