The amyloid beta protein gene is not duplicated in brains from patients with Alzheimer's disease.
Science
; 238(4827): 666-9, 1987 Oct 30.
Article
en En
| MEDLINE
| ID: mdl-2890207
ABSTRACT
Complementary DNAs (cDNAs) encoding portions of the amyloid beta protein were used to investigate possible amyloid gene duplication in sporadic Alzheimer's disease. A strategy employing two Eco RI restriction fragment length polymorphisms (RFLPs) detected by the amyloid cDNAs was used. RFLPs allow the detection of a 21 gene dosage in the DNA of any individual who is heterozygous for a particular RFLP. The amyloid gene regions homologous to the cDNAs used were not duplicated in the DNA from brains of individuals with sporadic Alzheimer's disease. Similar results were also obtained with a strategy employing a test for 32 gene dosage.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad de Alzheimer
/
Amiloide
Límite:
Humans
Idioma:
En
Revista:
Science
Año:
1987
Tipo del documento:
Article
País de afiliación:
Marruecos