Novel role of the nociceptin system as a regulator of glutamate transporter expression in developing astrocytes.
Glia
; 65(12): 2003-2023, 2017 12.
Article
en En
| MEDLINE
| ID: mdl-28906039
ABSTRACT
Our previous results showed that oligodendrocyte development is regulated by both nociceptin and its G-protein coupled receptor, the nociceptin/orphanin FQ receptor (NOR). The present in vitro and in vivo findings show that nociceptin plays a crucial conserved role regulating the levels of the glutamate/aspartate transporter GLAST/EAAT1 in both human and rodent brain astrocytes. This nociceptin-mediated response takes place during a critical developmental window that coincides with the early stages of astrocyte maturation. GLAST/EAAT1 upregulation by nociceptin is mediated by NOR and the downstream participation of a complex signaling cascade that involves the interaction of several kinase systems, including PI-3K/AKT, mTOR, and JAK. Because GLAST is the main glutamate transporter during brain maturation, these novel findings suggest that nociceptin plays a crucial role in regulating the function of early astrocytes and their capacity to support glutamate homeostasis in the developing brain.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Astrocitos
/
Receptores Opioides
/
Péptidos Opioides
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Regulación del Desarrollo de la Expresión Génica
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Sistema de Transporte de Aminoácidos X-AG
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Glia
Asunto de la revista:
NEUROLOGIA
Año:
2017
Tipo del documento:
Article