Effect of Water on the Chemical Stability of Amorphous Pharmaceuticals: 2. Deamidation of Peptides and Proteins.

Ohtake, Satoshi; Feng, Shaoxin; Shalaev, Evgenyi

Ohtake, Satoshi; Feng, Shaoxin; Shalaev, Evgenyi.

Afiliación

Ohtake S; Pfizer BioTherapeutics Pharmaceutical Sciences, Chesterfield, Missouri 63017.
Feng S; Pharmaceutical Development, Allergan plc, Irvine, California 92612.
Shalaev E; Pharmaceutical Development, Allergan plc, Irvine, California 92612. Electronic address: evgenyi.shalaev@allergan.com.

J Pharm Sci ; 107(1): 42-56, 2018 01.

Article en En | MEDLINE | ID: mdl-28923320

Asunto(s)

Péptidos/química; Proteínas/química; Agua/química; Química Farmacéutica/métodos; Estabilidad de Medicamentos; Liofilización/métodos; Cinética

Palabras clave

acid/base; amorphous; deamidation; dehydration; formulation; freeze drying/lyophilization; peptides; physical characterization; protein formulation; solid state Stability

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Péptidos / Agua / Proteínas Idioma: En Revista: J Pharm Sci Año: 2018 Tipo del documento: Article

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