Selective glucocorticoid receptor modulation inhibits cytokine responses in a canine model of mild endotoxemia.

Bartko, Johann; Derhaschnig, Ulla; Neels, Tania; Nabozny, Gerald H; Harcken, Christian; Leuschner, Jost; De Vries, Frerich; Jilma, Bernd

Bartko, Johann; Derhaschnig, Ulla; Neels, Tania; Nabozny, Gerald H; Harcken, Christian; Leuschner, Jost; De Vries, Frerich; Jilma, Bernd.

Afiliación

Bartko J; Department of Clinical Pharmacology, Medical University of Vienna, Austria; Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Vienna, Austria.
Derhaschnig U; Department of Clinical Pharmacology, Medical University of Vienna, Austria; Department of Emergency Medicine, Medical University of Vienna, Austria.
Neels T; Department of Clinical Pharmacology, Medical University of Vienna, Austria.
Nabozny GH; Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, USA.
Harcken C; Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, USA.
Leuschner J; LPT Laboratory of Pharmacology and Toxicology GmbH & Co. KG, Germany.
De Vries F; Boehringer Ingelheim Vetmedica GmbH, Ingelheim, Germany.
Jilma B; Department of Clinical Pharmacology, Medical University of Vienna, Austria. Electronic address: bernd.jilma@meduniwien.ac.at.

Pharmacol Res ; 125(Pt B): 215-223, 2017 Nov.

Article en En | MEDLINE | ID: mdl-28923543

Asunto(s)

Antiinflamatorios no Esteroideos/uso terapéutico; Benzamidas/uso terapéutico; Endotoxemia/tratamiento farmacológico; Piridinas/uso terapéutico; Pirimidinas/uso terapéutico; Pirroles/uso terapéutico; Receptores de Glucocorticoides/metabolismo; Animales; Antiinflamatorios no Esteroideos/farmacocinética; Antiinflamatorios no Esteroideos/farmacología; Benzamidas/farmacocinética; Benzamidas/farmacología; Huesos/metabolismo; Péptido C/sangre; Citocinas/sangre; Modelos Animales de Enfermedad; Perros; Endotoxemia/sangre; Insulina/sangre; Masculino; Osteocalcina/sangre; Piridinas/farmacocinética; Piridinas/farmacología; Pirimidinas/farmacocinética; Pirimidinas/farmacología; Pirroles/farmacocinética; Pirroles/farmacología

Palabras clave

Canine; Endotoxemia; GRMs; Glucocorticoids; Inflammation; Prednisolone

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piridinas / Pirimidinas / Pirroles / Benzamidas / Receptores de Glucocorticoides / Antiinflamatorios no Esteroideos / Endotoxemia Límite: Animals Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Austria

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