Mn(II) based T1 and T2 potential MRI contrast agent appended with tryptamine: Recognition moiety for Aß-plaques.
J Inorg Biochem
; 177: 76-81, 2017 12.
Article
en En
| MEDLINE
| ID: mdl-28926757
ABSTRACT
We report the synthesis and characterization of manganese(II) complexes having pentadentate ligands L1 (2,6-bis(1-(2-phenyl-2-(pyridin-2-yl)hydrazono)ethyl)pyridine), L2 (methyl 2,6-bis((E)-1-(2-phenyl-2-(pyridin-2yl)hydrazono)ethyl)isonicotinate), L3 (N-(2-(1H-indol-3-yl)ethyl)-2,6-bis((E)-1-(2-phenyl-2-(pyridin2yl)hydrazono)ethyl)isonicotiamide) and their application as dual contrast agents for simultaneous T1 and T2 weighted magnetic resonance imaging. Single crystal analysis of all the complexes [MnIIL1, MnIIL2 and MnIIL3] confirm the formation of novel seven-coordinate manganese complexes with an inner sphere water and perchlorate ion. The Magnetic Resonance Imaging (MRI) contrast agent [MnL2] was further modified by incorporating tryptamine as a binding moiety specific to Amyloid Beta-fibrils (Aß-fibrils) in Alzhiemer's disease (AD) and it's in vitro evaluation for specific binding with Aß-fibrils indicated as a bio-marker of AD.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
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Triptaminas
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Péptidos beta-Amiloides
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Medios de Contraste
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Complejos de Coordinación
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Manganeso
Idioma:
En
Revista:
J Inorg Biochem
Año:
2017
Tipo del documento:
Article
País de afiliación:
India