Active Site Metal Identity Alters Histone Deacetylase 8 Substrate Selectivity: A Potential Novel Regulatory Mechanism.

Castaneda, Carol Ann; Lopez, Jeffrey E; Joseph, Caleb G; Scholle, Michael D; Mrksich, Milan; Fierke, Carol A

Castaneda, Carol Ann; Lopez, Jeffrey E; Joseph, Caleb G; Scholle, Michael D; Mrksich, Milan; Fierke, Carol A.

Afiliación

Castaneda CA; Program in Chemical Biology, University of Michigan , Ann Arbor, Michigan 48109, United States.
Lopez JE; Program in Chemical Biology, University of Michigan , Ann Arbor, Michigan 48109, United States.
Joseph CG; Department of Medicinal Chemistry, University of Michigan , Ann Arbor, Michigan 48109, United States.
Scholle MD; Department of Chemistry and Department of Biomedical Engineering, Northwestern University , Evanston, Illinois 60208, United States.
Mrksich M; Department of Chemistry and Department of Biomedical Engineering, Northwestern University , Evanston, Illinois 60208, United States.
Fierke CA; Program in Chemical Biology, University of Michigan , Ann Arbor, Michigan 48109, United States.

Biochemistry ; 56(42): 5663-5670, 2017 10 24.

Article en En | MEDLINE | ID: mdl-28937750

Asunto(s)

Histona Desacetilasas/química; Hierro/química; Péptidos/química; Proteínas Represoras/química; Zinc/química; Acetilación; Catálisis; Dominio Catalítico; Histona Desacetilasas/metabolismo; Humanos; Hierro/metabolismo; Péptidos/metabolismo; Proteínas Represoras/metabolismo; Zinc/metabolismo

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Péptidos / Proteínas Represoras / Zinc / Histona Desacetilasas / Hierro Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Biochemistry Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos

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