Non-coding Transcription Instructs Chromatin Folding and Compartmentalization to Dictate Enhancer-Promoter Communication and T Cell Fate.

Isoda, Takeshi; Moore, Amanda J; He, Zhaoren; Chandra, Vivek; Aida, Masatoshi; Denholtz, Matthew; Piet van Hamburg, Jan; Fisch, Kathleen M; Chang, Aaron N; Fahl, Shawn P; Wiest, David L; Murre, Cornelis

Isoda, Takeshi; Moore, Amanda J; He, Zhaoren; Chandra, Vivek; Aida, Masatoshi; Denholtz, Matthew; Piet van Hamburg, Jan; Fisch, Kathleen M; Chang, Aaron N; Fahl, Shawn P; Wiest, David L; Murre, Cornelis.

Afiliación

Isoda T; Department of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA.
Moore AJ; Department of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA.
He Z; Department of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA.
Chandra V; Department of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA.
Aida M; Department of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA.
Denholtz M; Department of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA.
Piet van Hamburg J; Department of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA.
Fisch KM; Center for Computational Biology & Bioinformatics, Institute for Genomic Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Chang AN; Center for Computational Biology & Bioinformatics, Institute for Genomic Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Fahl SP; Blood Cell Development and Function, Fox Chase Cancer Center, 333 Cottman Avenue, PA, Philadelphia, PA 19111, USA.
Wiest DL; Blood Cell Development and Function, Fox Chase Cancer Center, 333 Cottman Avenue, PA, Philadelphia, PA 19111, USA.
Murre C; Department of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: cmurre@ucsd.edu.

Cell ; 171(1): 103-119.e18, 2017 Sep 21.

Article en En | MEDLINE | ID: mdl-28938112

Asunto(s)

Elementos de Facilitación Genéticos; Regiones Promotoras Genéticas; ARN no Traducido/genética; Proteínas Represoras/genética; Linfocitos T/citología; Proteínas Supresoras de Tumor/genética; Animales; Factor de Unión a CCCTC; Cromatina/metabolismo; Leucemia/genética; Región de Control de Posición; Linfoma/genética; Ratones; Lámina Nuclear/metabolismo; Proteínas Represoras/metabolismo; Linfocitos T/metabolismo; Timo/citología; Timo/metabolismo; Transcripción Genética

Palabras clave

CTCF; Non-coding transcription; T cell development; cohesin; compartmentalization; leukemia; loop extrusion; lymphoma; phase separation; single-loop domain

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Represoras / Linfocitos T / Elementos de Facilitación Genéticos / Regiones Promotoras Genéticas / ARN no Traducido / Proteínas Supresoras de Tumor Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Cell Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos

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