Gain-of-function mutant p53 activates small GTPase Rac1 through SUMOylation to promote tumor progression.

Yue, Xuetian; Zhang, Cen; Zhao, Yuhan; Liu, Juan; Lin, Alan W; Tan, Victor M; Drake, Justin M; Liu, Lianxin; Boateng, Michael N; Li, Jun; Feng, Zhaohui; Hu, Wenwei

Yue, Xuetian; Zhang, Cen; Zhao, Yuhan; Liu, Juan; Lin, Alan W; Tan, Victor M; Drake, Justin M; Liu, Lianxin; Boateng, Michael N; Li, Jun; Feng, Zhaohui; Hu, Wenwei.

Afiliación

Yue X; Rutgers Cancer Institute of New Jersey, the State University of New Jersey, New Brunswick, New Jersey 08903, USA.
Zhang C; Department of Radiation Oncology, the State University of New Jersey, New Brunswick, New Jersey 08903, USA.
Zhao Y; Rutgers Cancer Institute of New Jersey, the State University of New Jersey, New Brunswick, New Jersey 08903, USA.
Liu J; Department of Radiation Oncology, the State University of New Jersey, New Brunswick, New Jersey 08903, USA.
Lin AW; Rutgers Cancer Institute of New Jersey, the State University of New Jersey, New Brunswick, New Jersey 08903, USA.
Tan VM; Department of Radiation Oncology, the State University of New Jersey, New Brunswick, New Jersey 08903, USA.
Drake JM; Rutgers Cancer Institute of New Jersey, the State University of New Jersey, New Brunswick, New Jersey 08903, USA.
Liu L; Department of Radiation Oncology, the State University of New Jersey, New Brunswick, New Jersey 08903, USA.
Boateng MN; Rutgers Cancer Institute of New Jersey, the State University of New Jersey, New Brunswick, New Jersey 08903, USA.
Li J; Rutgers Cancer Institute of New Jersey, the State University of New Jersey, New Brunswick, New Jersey 08903, USA.
Feng Z; Department of Medicine, Robert Wood Johnson Medical School, Rutgers University, the State University of New Jersey, New Brunswick, New Jersey 08903, USA.
Hu W; Rutgers Cancer Institute of New Jersey, the State University of New Jersey, New Brunswick, New Jersey 08903, USA.

Genes Dev ; 31(16): 1641-1654, 2017 08 15.

Article en En | MEDLINE | ID: mdl-28947497

Asunto(s)

Carcinogénesis/genética; Mutación; Sumoilación; Proteína p53 Supresora de Tumor/genética; Proteína de Unión al GTP rac1/metabolismo; Línea Celular; Línea Celular Tumoral; Cisteína Endopeptidasas/metabolismo; Progresión de la Enfermedad; Humanos; Metástasis de la Neoplasia; Neoplasias/enzimología; Neoplasias/metabolismo; Neoplasias/patología; Proteína p53 Supresora de Tumor/metabolismo

Palabras clave

Rac1; SUMOylation; gain of function; metastasis; mutant p53; tumorigenesis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteína p53 Supresora de Tumor / Proteína de Unión al GTP rac1 / Sumoilación / Carcinogénesis / Mutación Límite: Humans Idioma: En Revista: Genes Dev Asunto de la revista: BIOLOGIA MOLECULAR Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos

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