Potential Medication Treatment According to Pathological Mechanisms in Abdominal Aortic Aneurysm.
J Cardiovasc Pharmacol
; 71(1): 46-57, 2018 01.
Article
en En
| MEDLINE
| ID: mdl-28953105
ABSTRACT
Abdominal aortic aneurysm (AAA) is a vascular disease with high mortality. Because of the lack of effective medications to stop or reverse the progression of AAA, surgical operation has become the most predominant recommendation of treatment for patients. There are many potential mechanisms, including inflammation, smooth muscle cell apoptosis, extracellular matrix degradation, oxidative stress, and so on, involving in AAA pathogenesis. According to those mechanisms, some potential therapeutic drugs have been proposed and tested in animal models and even in clinical trials. This review focuses on recent advances in both pathogenic mechanisms and potential pharmacologic therapies of AAA.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Aorta Abdominal
/
Fármacos Cardiovasculares
/
Aneurisma de la Aorta Abdominal
Tipo de estudio:
Etiology_studies
/
Guideline
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Animals
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Cardiovasc Pharmacol
Año:
2018
Tipo del documento:
Article
País de afiliación:
China