Transcriptional memory of cells of origin overrides ß-catenin requirement of MLL cancer stem cells.

Siriboonpiputtana, Teerapong; Zeisig, Bernd B; Zarowiecki, Magdalena; Fung, Tsz Kan; Mallardo, Maria; Tsai, Chiou-Tsun; Lau, Priscilla Nga Ieng; Hoang, Quoc Chinh; Veiga, Pedro; Barnes, Jo; Lynn, Claire; Wilson, Amanda; Lenhard, Boris; So, Chi Wai Eric

Siriboonpiputtana, Teerapong; Zeisig, Bernd B; Zarowiecki, Magdalena; Fung, Tsz Kan; Mallardo, Maria; Tsai, Chiou-Tsun; Lau, Priscilla Nga Ieng; Hoang, Quoc Chinh; Veiga, Pedro; Barnes, Jo; Lynn, Claire; Wilson, Amanda; Lenhard, Boris; So, Chi Wai Eric.

Afiliación

Siriboonpiputtana T; Department of Haematological Medicine, Division of Cancer Studies, Leukemia and Stem Cell Biology Team, King's College London, London, UK.
Zeisig BB; Department of Haematological Medicine, Division of Cancer Studies, Leukemia and Stem Cell Biology Team, King's College London, London, UK.
Zarowiecki M; Department of Haematological Medicine, Division of Cancer Studies, Leukemia and Stem Cell Biology Team, King's College London, London, UK.
Fung TK; Department of Haematological Medicine, Division of Cancer Studies, Leukemia and Stem Cell Biology Team, King's College London, London, UK.
Mallardo M; Department of Haematological Medicine, Division of Cancer Studies, Leukemia and Stem Cell Biology Team, King's College London, London, UK.
Tsai CT; Department of Haematological Medicine, Division of Cancer Studies, Leukemia and Stem Cell Biology Team, King's College London, London, UK.
Lau PNI; Department of Haematological Medicine, Division of Cancer Studies, Leukemia and Stem Cell Biology Team, King's College London, London, UK.
Hoang QC; Department of Haematological Medicine, Division of Cancer Studies, Leukemia and Stem Cell Biology Team, King's College London, London, UK.
Veiga P; Department of Haematological Medicine, Division of Cancer Studies, Leukemia and Stem Cell Biology Team, King's College London, London, UK.
Barnes J; Department of Haematological Medicine, Division of Cancer Studies, Leukemia and Stem Cell Biology Team, King's College London, London, UK.
Lynn C; Department of Haematological Medicine, Division of Cancer Studies, Leukemia and Stem Cell Biology Team, King's College London, London, UK.
Wilson A; Department of Haematological Medicine, Division of Cancer Studies, Leukemia and Stem Cell Biology Team, King's College London, London, UK.
Lenhard B; Faculty of Medicine, Institute of Clinical Sciences, Imperial College London, London, UK.
So CWE; Computational Regulatory Genomics, MRC London Institute of Medical Sciences, London, UK.

EMBO J ; 36(21): 3139-3155, 2017 11 02.

Article en En | MEDLINE | ID: mdl-28978671

Asunto(s)

Regulación Leucémica de la Expresión Génica; Proteínas de Homeodominio/genética; Leucemia Mieloide Aguda/genética; Células Madre Neoplásicas/metabolismo; Transcripción Genética; beta Catenina/genética; Animales; Antígenos Ly/genética; Antígenos Ly/metabolismo; Proliferación Celular; Supervivencia Celular; Modelos Animales de Enfermedad; Perfilación de la Expresión Génica; Células Madre Hematopoyéticas/metabolismo; Células Madre Hematopoyéticas/patología; Proteínas de Homeodominio/antagonistas & inhibidores; Proteínas de Homeodominio/metabolismo; Humanos; Leucemia Mieloide Aguda/metabolismo; Leucemia Mieloide Aguda/mortalidad; Leucemia Mieloide Aguda/patología; Proteínas de la Membrana/genética; Proteínas de la Membrana/metabolismo; Ratones; Ratones Endogámicos C57BL; Ratones Noqueados; Células Madre Neoplásicas/patología; Proteína-Arginina N-Metiltransferasas/genética; Proteína-Arginina N-Metiltransferasas/metabolismo; Proteínas Proto-Oncogénicas c-kit/genética; Proteínas Proto-Oncogénicas c-kit/metabolismo; ARN Interferente Pequeño/genética; ARN Interferente Pequeño/metabolismo; Proteínas Represoras/genética; Proteínas Represoras/metabolismo; Transducción de Señal; Análisis de Supervivencia; beta Catenina/metabolismo

Palabras clave

Hoxa9; MLL leukemia; Prmt1; Wnt/ßcatenin; cells of origin

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Transcripción Genética / Células Madre Neoplásicas / Leucemia Mieloide Aguda / Regulación Leucémica de la Expresión Génica / Proteínas de Homeodominio / Beta Catenina Tipo de estudio: Prognostic_studies Idioma: En Revista: EMBO J Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido

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